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Synthesis, studies and in vitro antibacterial activity of some 5-(thiophene-2-yl)-phenyl pyrazoline derivatives
Joint Authors
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 5 (31 Dec. 2014), pp.411-417, 7 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
In the present investigation, a novel series of pyrazolines 2a–2d were synthesized by the cyclization of various -1-[2-(alkoxy) phenyl]-3-(thiophen-2-yl) prop-2-en-1-one 1a–1d with N-substituted phenyl hydrazine and thiosemicarbazide in the presence of CH3COOH and NaOH in ethanol which lead to the formation of new pyrazolines.
The structures of these compounds were elucidated by, IR, 1H-NMR, 13C-NMR, ESI-MS spectral data and their purities were confirmed by elemental analyes.
The in vitro antibacterial activity of these compounds was evaluated against two Grampositive and two Gram-negative bacteria Aeromonas hydrophila, Yersinia enterocolitica, Listeria monocytogenes, and Staphylococcus aureus by microdilution method and then the minimum inhibitory concentration (MIC) of these compounds was determined.
The results showed that compounds 1-[2-(benzyloxy) phenyl]-5-(thiophen-2-yl)-1-phenyl-4, 5-dihydro-1H-pyrazol-4-yl (2b) and 1-[2-(naphthalen-2-ylmethoxy) phenyl]-5-(thiophene-2-yl)-1-phenyl-4, 5-dihydro-1H-pyrazole-4-yl (2d) showed most promising antibacterial activity as compared to the antibiotics gentamicin and tetracycline in (Tables 1 and 2).
American Psychological Association (APA)
Rani, Mamta& Muhammad, Yusuf. 2014. Synthesis, studies and in vitro antibacterial activity of some 5-(thiophene-2-yl)-phenyl pyrazoline derivatives. Journal of Saudi Chemical Society،Vol. 18, no. 5, pp.411-417.
https://search.emarefa.net/detail/BIM-412433
Modern Language Association (MLA)
Rani, Mamta& Muhammad, Yusuf. Synthesis, studies and in vitro antibacterial activity of some 5-(thiophene-2-yl)-phenyl pyrazoline derivatives. Journal of Saudi Chemical Society Vol. 18, no. 5 (2014), pp.411-417.
https://search.emarefa.net/detail/BIM-412433
American Medical Association (AMA)
Rani, Mamta& Muhammad, Yusuf. Synthesis, studies and in vitro antibacterial activity of some 5-(thiophene-2-yl)-phenyl pyrazoline derivatives. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 5, pp.411-417.
https://search.emarefa.net/detail/BIM-412433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 417
Record ID
BIM-412433