Controlled-release and antibacterial studies of doxycycline-loaded poly (E-caprolactone) microspheres
Joint Authors
Raval, Jignesh P.
Patel, Pradip S.
Naik, Deep R.
Amin, Keyur A.
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 5 (31 Dec. 2014), pp.566-573, 8 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract EN
The objective of the present study is to achieve doxycycline’s maximum therapeutic efficacy.
Doxycycline-loaded poly (e-caprolactone) microspheres were prepared by water-in-oil-inwater (w / o / w) double emulsion solvent evaporation technique with different formulation variables such as concentrations of drug and polymer.
The effects of these variables on surface morphology, particle size distribution, encapsulation efficiency, and in vitro release behavior were examined.
To observe the nature of microspheres, X-ray diffraction studies were carried out.
The release data obtained were determined using various kinetic models and Korsmeyer–Peppas model showed an acceptable regression value for all compositions.
Antibacterial efficiency of doxycycline-loaded poly (e-caprolactone) microspheres were assessed by determining Minimum Inhibition Concentration (MIC) by standard tube dilution method against four standard pathogenic strains.
The in vitro drug release studies were carried out in phosphate buffer solution (pH 7.2).
The results showed marked retardation of doxycycline release and higher percentage of polymer gave longer drug release profile.
This may definitely provide a useful controlled-release drug therapy and also prove to be effective over a long period of time (76 h).
American Psychological Association (APA)
Raval, Jignesh P.& Naik, Deep R.& Amin, Keyur A.& Patel, Pradip S.. 2014. Controlled-release and antibacterial studies of doxycycline-loaded poly (E-caprolactone) microspheres. Journal of Saudi Chemical Society،Vol. 18, no. 5, pp.566-573.
https://search.emarefa.net/detail/BIM-412962
Modern Language Association (MLA)
Raval, Jignesh P.…[et al.]. Controlled-release and antibacterial studies of doxycycline-loaded poly (E-caprolactone) microspheres. Journal of Saudi Chemical Society Vol. 18, no. 5 (2014), pp.566-573.
https://search.emarefa.net/detail/BIM-412962
American Medical Association (AMA)
Raval, Jignesh P.& Naik, Deep R.& Amin, Keyur A.& Patel, Pradip S.. Controlled-release and antibacterial studies of doxycycline-loaded poly (E-caprolactone) microspheres. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 5, pp.566-573.
https://search.emarefa.net/detail/BIM-412962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 572-573
Record ID
BIM-412962