Synthesis, characterization, and biological activity of novel mixed ligand complexes of zinc (II) diclofenac or indomethacin with nitrogen based ligands
Other Title(s)
تحضير و تشخيص و دراسة الفعالية الحيوية لمركبات تحتوي أيون الزنك الثنائي و الدكلوفيناك أو الاندوميثاسين و قواعد نيتروجينية
Dissertant
Thesis advisor
Comitee Members
University
Birzeit University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2014
English Abstract
Fourteen novel Zn(II) complexes, [Zn2(diclo)2(H2O)2] (1), [Zn2(Indo)4] (2), [Zn(diclo)4(pico)2] (3), [Zn2(indo)4(pico)2] (4), [Zn(diclo)2(apy)2] (5), [Zn(indo)2(apy)2] (6), [Zn(diclo)2(ampy)] (7), [Zn(indo)2(ampy)] (8), [Zn(diclo)2(phen)] (9) [Zn(diclo)2(phen)] (9), [Zn(indo)2(phen)] (10), [Zn(diclo)2(dmph)] (11), [Zn(indo)2(dmph)] (12), [Zn(diclo)2(admp)2] (13), [Zn(indo)2(admp)2] (14), were synthesized and characterized by means of IR, 1H-NMR, 13C{H}-NMR and UV-Vis spectrometry.
The crystal structures of complexes (1), (4), (5), (11) were determined by single crystal X-ray diffraction.
Melting point and solubility of the synthesized complexes were determined.
The in-vitro anti-bacterial activity of the synthesized complexes was screened using agar diffusion assay against two strains of Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and two strains of Gram-positive bacteria (Staphylococcus aureus, Listeria monocytogenes), the results showed higher activity against Pseudomonas aeruginosa and Staphylococcus aureus, in comparison with diclofenac, indomethacin and free nitogen ligands.
Main Subjects
No. of Pages
179
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental.
Chapter Three : Results and discussion.
Conclusion.
References.
American Psychological Association (APA)
Jabali, Baha H.. (2014). Synthesis, characterization, and biological activity of novel mixed ligand complexes of zinc (II) diclofenac or indomethacin with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-412986
Modern Language Association (MLA)
Jabali, Baha H.. Synthesis, characterization, and biological activity of novel mixed ligand complexes of zinc (II) diclofenac or indomethacin with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University. (2014).
https://search.emarefa.net/detail/BIM-412986
American Medical Association (AMA)
Jabali, Baha H.. (2014). Synthesis, characterization, and biological activity of novel mixed ligand complexes of zinc (II) diclofenac or indomethacin with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-412986
Language
English
Data Type
Arab Theses
Record ID
BIM-412986
