An efficient synthesis of new thiazolidin-4-one fused s-triazines as potential antimicrobial and anticancer agents
Joint Authors
Patel, Amit B.
Chikhalia, Kishur H.
Kumari, Premlata
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 5 (31 Dec. 2014), pp.646-656, 11 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
As a part of our endeavor toward the synthesis of new heterocyclic bioactive agents, two series of thiazolidin-4-one fused s-triazines were synthesized by applying an efficient palladium catalyzed C–C Suzuki coupling using catalyst system Pd (OAC) 2, Xphos and K3PO4 as a base in toluene solvent.
Moreover, the synthesized analogs were further screened for their in vitro antimicrobial as well as anticancer efficacy against prostate cancer PC3 cells.
Some compounds displayed remarkable antimicrobial activity and noticeable anticancer activity.
It was observed that, both benzonitrile and nicotinonitrile are essential to increase the different pharmacological activities.
The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and MS analysis.
American Psychological Association (APA)
Patel, Amit B.& Chikhalia, Kishur H.& Kumari, Premlata. 2014. An efficient synthesis of new thiazolidin-4-one fused s-triazines as potential antimicrobial and anticancer agents. Journal of Saudi Chemical Society،Vol. 18, no. 5, pp.646-656.
https://search.emarefa.net/detail/BIM-414171
Modern Language Association (MLA)
Patel, Amit B.…[et al.]. An efficient synthesis of new thiazolidin-4-one fused s-triazines as potential antimicrobial and anticancer agents. Journal of Saudi Chemical Society Vol. 18, no. 5 (2014), pp.646-656.
https://search.emarefa.net/detail/BIM-414171
American Medical Association (AMA)
Patel, Amit B.& Chikhalia, Kishur H.& Kumari, Premlata. An efficient synthesis of new thiazolidin-4-one fused s-triazines as potential antimicrobial and anticancer agents. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 5, pp.646-656.
https://search.emarefa.net/detail/BIM-414171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 655-656
Record ID
BIM-414171