Synthesis, spectral characterization and biological evaluation of novel 1-(2-(4, 5-dimethyl-2-phenyl-1H-imidazol-1-yl) ethyl) piperazine derivatives
Joint Authors
Krishnasamy, kemalatha
Rajkumar, R.
Kamaraj, A.
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 5 (31 Dec. 2014), pp.735-743, 9 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
A simple, highly useful synthesis of 1-(2-(4, 5-dimethyl-2-phenyl-1H-imidazol-1-yl) ethyl) piperazine derivatives is achieved by a four component cyclo condensation of diacetyl, aromatic aldehyde, 2-(piperazin-1-yl) ethanamine and ammonium acetate using SO4 2 / Y2O3 as a catalyst in ethanol.
The synthesized compounds were characterized by IR, 1H and 13C NMR and mass spectral studies.
All the synthesized compounds were screened for their in vitro antimicrobial studies.
Among the newly synthesized compounds 5d, 5e, 5h and 5m showed excellent antibacterial and antifungal activities when compared to the standard drugs.
American Psychological Association (APA)
Rajkumar, R.& Kamaraj, A.& Krishnasamy, kemalatha. 2014. Synthesis, spectral characterization and biological evaluation of novel 1-(2-(4, 5-dimethyl-2-phenyl-1H-imidazol-1-yl) ethyl) piperazine derivatives. Journal of Saudi Chemical Society،Vol. 18, no. 5, pp.735-743.
https://search.emarefa.net/detail/BIM-414310
Modern Language Association (MLA)
Rajkumar, R.…[et al.]. Synthesis, spectral characterization and biological evaluation of novel 1-(2-(4, 5-dimethyl-2-phenyl-1H-imidazol-1-yl) ethyl) piperazine derivatives. Journal of Saudi Chemical Society Vol. 18, no. 5 (2014), pp.735-743.
https://search.emarefa.net/detail/BIM-414310
American Medical Association (AMA)
Rajkumar, R.& Kamaraj, A.& Krishnasamy, kemalatha. Synthesis, spectral characterization and biological evaluation of novel 1-(2-(4, 5-dimethyl-2-phenyl-1H-imidazol-1-yl) ethyl) piperazine derivatives. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 5, pp.735-743.
https://search.emarefa.net/detail/BIM-414310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 743
Record ID
BIM-414310