Thromboprophylaxis in women with unexplained consecutive recurrent miscarriages

Abstract EN

Objective : To compare the effect of low dose aspirin and enoxaparin on pregnancy in women with recurrent miscarriage.

Patients& Methods : Randomized controlled trail, conducted in Basrah Maternity and Child Hospital during the period from January 2012 till April 2013.

Participants were 221 pregnant women aged 18-41 years with history of at least 2 previous miscarriage without apparent causes.

They were divided into 2 groups ; the first group included 111 were given enoxaparin and the second group involved 108 which were given aspirin.

Results : In both groups (75 %) of patients had negative serological test for thrombophilia.

Enoxaparin group had higher significant incidence of term delivery (86 %) with less incidence of preterm delivery (4.5 %) and less early pregnancy loss (8 %).

No significant differences in obstetrical complication but higher incidence of abdominal delivery in both groups.

Higher incidence of postpartum hemorrhage in the enoxaparin group in comparison with aspirin group and no significant systemic adverse effect of enoxaparin were noticed on the first group.

Conclusion : Since postpartum hemorrhage is treatable, low molecular weight heparin is safe and effective for treating, preventing thrombosis and achieving successful pregnancy.