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Effect of thyroid dysfunction on hemoglobin A1 c in polycystic ovary patients during ovulation induction trials
Joint Authors
Salman, Abd al-Ali H.
Sadiq, Hanan L.
Mahdi, Hibah S.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 56, Issue 2 (30 Jun. 2014), pp.211-215, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2014-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders leading to infertility.
Majority of women with PCOS have insulin resistance and elevated hemoglobin Ale.
The presence of thyroid dysfunction may affect the levels of HbAlc and the results of ovulation induction programs.
Objectives : To evaluate the level of serum hemoglobin Ale according to the type of thyroid dysfunction in polycystic ovary patients during ovarian stimulation trials.
Patients and Methods : Eighty three polycystic ovary patients were enrolled in this study, attending the infertility clinic in Al-Yarmouk Teaching Hospital, in the period between November 2012 and May 2013.
After thorough history and examination blood samples were withdrawn for the estimation of LH, FSH, testosterone, prolactin, TSH, T3, T4 and A1C in day 2 or 3 of the menstrual cycle, Progesterone was determined in day 21 of the cycle.
Ultrasound was done also at cycle day 3 for antral follicles measurements.
After diagnosing PCOS the patients were divided into 3 groups, euthyroid group (control), hypothyroid and hyperthyroid groups.
Ovulation induction treatment was given and ultrasound was done at the day of hCG injection.
Results : There was no significant difference between control and patients groups regarding age (26.31 ± 5.04 Vs 27.17 ± 5.76) and BMI (31.7 ± 5.69Vs 29.25 ± 6.28).
HbAlc level was significantly different between the control and patients group with a significant positive correlation between HbAlc and TSH.
In clomiphene citrate treated groups, Hb Ale level, the number of antral follicles and the size of follicles at day of hCG injection were not significantly different between the patients and control groups.
Conclusions : HbAlc level is significantly affected by thyroid dysfunction in PCOS patients as it is higher in the Hypothyroid group and lower in the Hyperthyroid group.
Using Clomiphene citrate in PCOS does not significantly increase the mean size of follicles after ovarian stimulation in patients with thyroid dysfunction from that in Euthyroid ones.
American Psychological Association (APA)
Mahdi, Hibah S.& Sadiq, Hanan L.& Salman, Abd al-Ali H.. 2014. Effect of thyroid dysfunction on hemoglobin A1 c in polycystic ovary patients during ovulation induction trials. Journal of the Faculty of Medicine Baghdad،Vol. 56, no. 2, pp.211-215.
https://search.emarefa.net/detail/BIM-419525
Modern Language Association (MLA)
Mahdi, Hibah S.…[et al.]. Effect of thyroid dysfunction on hemoglobin A1 c in polycystic ovary patients during ovulation induction trials. Journal of the Faculty of Medicine Baghdad Vol. 56, no. 2 (2014), pp.211-215.
https://search.emarefa.net/detail/BIM-419525
American Medical Association (AMA)
Mahdi, Hibah S.& Sadiq, Hanan L.& Salman, Abd al-Ali H.. Effect of thyroid dysfunction on hemoglobin A1 c in polycystic ovary patients during ovulation induction trials. Journal of the Faculty of Medicine Baghdad. 2014. Vol. 56, no. 2, pp.211-215.
https://search.emarefa.net/detail/BIM-419525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 214-215
Record ID
BIM-419525