Effects of coenzyme q10 supplementation on serum lipoproteins, plasma fibrinogen, and blood pressure in patients with hyperlipidemia and myocardial infarction
Joint Authors
Zarrati, Mitra
Shidfar, Farzad
Muhsini, Muna
Vafa, Muhammad Riza
Hajimiresmail, Sayyid Javad
Forushani, Abbas Rahimi
Bitarafan, Vida
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 10 (31 Oct. 2014), pp.1-7, 7 p.
Publisher
Publication Date
2014-10-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Low plasma concentrations of coenzyme Q10 (CoQ10) have been associated with concentration of lipoproteins and other factors contributing to coronary heart diseases.
Objectives : The present investigation aimed to improve the blood pressure and serum lipoproteins concentration in patients with myocardial infarction (MI) by CoQ10 supplementation.
Patients and Methods : In this randomized double-blinded controlled clinical trial, 52 Iranian patients with hyperlipidemia and MI were recruited to examine the effect of CoQ10 on serum total cholesterol (TC), LDL-C, HDL-C, triglyceride (TG), LDL-C / HDL-C ratio, TC / HDL-C ratio, fibrinogen, systolic blood pressure (SBP) and diastolic blood pressure (DBP).
Individuals were randomly allocated to two groups for receiving either 200 mg / d of CoQ10 or placebo for 12 weeks.
Results : There were not significant differences in serum LDL-C (2.70 ± 0.31 vs.
2.70 ± 0.35 mmol / L), TC (4.47 ± 0.33 vs.
4.93 ± 0.57 mmol / L), TG (2.48 ± 0.12 vs.
2.25 ± 0.69 mmol / L), and fibrinogen (2.08 ± 0.99 vs.
38.7 ± 0.64 mg / dL) between CoQ10 and placebo groups.
After 12 weeks, a significant enhancement in serum HDL-C (1.44 ± 0.18 vs.
1.14 ± 0.18 mmol / L) level was observed between groups after the supplementation (P < 0.001).
A significant reduction of TC, LDL-C, and fibrinogen and a significant increase in HDL-C concentration was observed in CoQ10 group after intervention (P < 0.001).
Our assessment demonstrated statistically significant differences between the two groups in SBP and DBP after intervention (P < 0.001).
ANCOVA also revealed significant differences in the ratio of LDL-C / HDL-C and TC / HDL-C between the two groups (1.89 ± 0.42 vs.
2.39 ± 0.38, P = 0.002 ; and 3.2 ± 0.5 vs.
4.24 ± 0.66, P = 0.01, respectively).
A significant reduction of LDL-C / HDL-C and TC / HDL-C was observed in CoQ10 group (P < 0.001).
Conclusions : Twelve-week supplementation with CoQ10 in patients with hyperlipidemia and MI can improve blood pressure, serum HDL-C as well as LDL-C / HDL-C and TC / HDL-C ratios ; therefore, it might decrease the risk of frequent MI.
American Psychological Association (APA)
Muhsini, Muna& Vafa, Muhammad Riza& Hajimiresmail, Sayyid Javad& Zarrati, Mitra& Forushani, Abbas Rahimi& Bitarafan, Vida…[et al.]. 2014. Effects of coenzyme q10 supplementation on serum lipoproteins, plasma fibrinogen, and blood pressure in patients with hyperlipidemia and myocardial infarction. Iranian Red Crescent Medical Journal،Vol. 16, no. 10, pp.1-7.
https://search.emarefa.net/detail/BIM-419639
Modern Language Association (MLA)
Muhsini, Muna…[et al.]. Effects of coenzyme q10 supplementation on serum lipoproteins, plasma fibrinogen, and blood pressure in patients with hyperlipidemia and myocardial infarction. Iranian Red Crescent Medical Journal Vol. 16, no. 10 (Oct. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-419639
American Medical Association (AMA)
Muhsini, Muna& Vafa, Muhammad Riza& Hajimiresmail, Sayyid Javad& Zarrati, Mitra& Forushani, Abbas Rahimi& Bitarafan, Vida…[et al.]. Effects of coenzyme q10 supplementation on serum lipoproteins, plasma fibrinogen, and blood pressure in patients with hyperlipidemia and myocardial infarction. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 10, pp.1-7.
https://search.emarefa.net/detail/BIM-419639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-419639