The scope of clinical morbidity in sickle cell trait
Author
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 4 (31 Oct. 2014), pp.319-326, 8 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Sickle cell trait (SCT), the heterozygous state of the sickle hemoglobin beta globin gene (HbAS) is carried by as many as 100 million individuals including up to 25% of the population in some regions of the World.
Sickle cell trait is the best-characterized genetic polymorphism known to protect against falciparum malaria.
Although SCT was initially considered as a benign condition, data are accumulating of serious morbidities in SCT individuals including increased incidence of hematuria, renal papillary necrosis, renal failure and malignancy, thromboembolic disorders, splenic infarction as a high altitude complication, and exercise-related rhabdomyolysis and sudden death.
Despite these associations, the average life span of individuals with sickle cell trait is similar to that of the general population.
Nonetheless, given the large number of people with sickle cell trait, it is important that physicians be aware of these associations.
The aim of this article is to review publications reporting and discussing morbidities in SCT individuals.
American Psychological Association (APA)
Tantawi, Azzah A. G.. 2014. The scope of clinical morbidity in sickle cell trait. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 4, pp.319-326.
https://search.emarefa.net/detail/BIM-422408
Modern Language Association (MLA)
Tantawi, Azzah A. G.. The scope of clinical morbidity in sickle cell trait. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 4 (Oct. 2014), pp.319-326.
https://search.emarefa.net/detail/BIM-422408
American Medical Association (AMA)
Tantawi, Azzah A. G.. The scope of clinical morbidity in sickle cell trait. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 4, pp.319-326.
https://search.emarefa.net/detail/BIM-422408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 324-326
Record ID
BIM-422408