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Study of toll-like receptor 7 expression and interferon a in Egyptian patients with chronic hepatitis c infection and hepatocellular carcinoma
Joint Authors
Abd Allah, Hibah M. I.
Zaki, Wafa K.
Abd al-Rauf, Tahany A.
Ahmad, Ala
Abu Zayd, Muna
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 4 (31 Oct. 2014), pp.387-392, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Hepatitis C virus is considered to be one of the most important devastating causes of chronic hepatitis, cirrhosis, and hepatic cellular carcinoma.
Toll-like receptor 7 (TLR7) is a pathogen-recognition receptor that is expressed on innate immune cells.
It recognizes viral RNA which induces its activation with a subsequent increase in IFN-a transcription.
It has been postulated that HCV may cause down regulation of these receptors as one of immune evading mechanisms that participate in viral persistence.
The aim of the work: Was to investigate the expression of TLR7 in peripheral blood of patients with chronic HCV infections and patients with HCC, comparing it with normal individuals, and correlating it with both serum levels of IFN-a and viral load.
Results : The results of this study showed a significant decrease in TLR7 expression in patients with chronic HCV and no detection at all in patients with HCC, in addition a significant negative correlation was observed between levels of TLR7expression and interferon a when compared to viral load.
Conclusion : Down regulation of TLR7 expression in HCV and HCC patients may contribute to the decrease of IFN-a and increase in viral load.
These results raise the possibility that by targeting TLR7 with high affinity pharmacological stimulants may be able to control HCV infection by induction of IFN-a and direct activation of antiviral mechanisms in hepatocytes.
Additionally, they provide insight about the potential use of TLR7 as a new set of molecular markers for prognosis and outcomes of chronic HCV infection and HCC.
American Psychological Association (APA)
Abd al-Rauf, Tahany A.& Ahmad, Ala& Zaki, Wafa K.& Abd Allah, Hibah M. I.& Abu Zayd, Muna. 2014. Study of toll-like receptor 7 expression and interferon a in Egyptian patients with chronic hepatitis c infection and hepatocellular carcinoma. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 4, pp.387-392.
https://search.emarefa.net/detail/BIM-422759
Modern Language Association (MLA)
Abd al-Rauf, Tahany A.…[et al.]. Study of toll-like receptor 7 expression and interferon a in Egyptian patients with chronic hepatitis c infection and hepatocellular carcinoma. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 4 (Oct. 2014), pp.387-392.
https://search.emarefa.net/detail/BIM-422759
American Medical Association (AMA)
Abd al-Rauf, Tahany A.& Ahmad, Ala& Zaki, Wafa K.& Abd Allah, Hibah M. I.& Abu Zayd, Muna. Study of toll-like receptor 7 expression and interferon a in Egyptian patients with chronic hepatitis c infection and hepatocellular carcinoma. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 4, pp.387-392.
https://search.emarefa.net/detail/BIM-422759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 392
Record ID
BIM-422759