Association of hydrocarbon exposure with glomerulonephritis in Nigerians : a case control study
Joint Authors
Arogundade, F. A.
Ishola, D. A.
Sanusi, A. A.
Akinsola, A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 17, Issue 1 (28 Feb. 2006), pp.82-89, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2006-02-28
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Glomerulonephritis (GN) is a major cause of CRF in Nigerians.
Experimental evidence and clinical studies mostly in Caucasian subjects have associated hydrocarbon (HC) exposure with GN.
We conducted a case-control study using a questionnaire-based quantitative HC exposure measurement to compare lifetime HC exposure levels between Nigerian patients with GN-induced CRF and matched healthy control subjects.
Fifty consecutive patients with CRF from GN were compared with age and sex matched group of 45 healthy controls.
A questionnaire designed to assess the sources, duration and intensity of HC exposure was used to compute an HC exposure score (HES) for each participant and the scores for the two groups were then compared.
The HES was significantly higher in the patients (score ± SEM) of 2307.5 ± 698.8 vs.
53.4 ± 16.5 ; p < 0.001.
The HES was dichotomised by classifying all study subjects within the upper third of scores as a high-exposure sub-group.
A significantly higher proportion of patients had high exposure (p < 0.002).
Logistic regression analysis excluded age and gender as confounding factors and determined a greater than four-fold risk of GN-induced CRF with high HC exposure (OR 4.3 ; 95 % CI 1.7 - 11).
In conclusion, our findings suggest that HC exposure is a significant risk factor for GN in Nigerians with CRF.
Exposure limitation could help to reduce the burden of CRF in the country.
American Psychological Association (APA)
Ishola, D. A.& Sanusi, A. A.& Arogundade, F. A.& Akinsola, A.. 2006. Association of hydrocarbon exposure with glomerulonephritis in Nigerians : a case control study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 17, no. 1, pp.82-89.
https://search.emarefa.net/detail/BIM-42460
Modern Language Association (MLA)
Ishola, D. A.…[et al.]. Association of hydrocarbon exposure with glomerulonephritis in Nigerians : a case control study. Saudi Journal of Kidney Diseases and Transplantation Vol. 17, no. 1 (Feb. 2006), pp.82-89.
https://search.emarefa.net/detail/BIM-42460
American Medical Association (AMA)
Ishola, D. A.& Sanusi, A. A.& Arogundade, F. A.& Akinsola, A.. Association of hydrocarbon exposure with glomerulonephritis in Nigerians : a case control study. Saudi Journal of Kidney Diseases and Transplantation. 2006. Vol. 17, no. 1, pp.82-89.
https://search.emarefa.net/detail/BIM-42460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 87-89
Record ID
BIM-42460