Synthesis of some new 4-oxo-thiazolidines, tetrazole and triazole derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized
Author
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 6 (31 Dec. 2014), pp.893-901, 9 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
A new heterocyclic derivative of 2-mercaptobenzothiazole (MBT) comprising 4-oxothiazolidines, tetrazole and triazole, through the reaction of (MBT) with hydrazine hydrate obtained 2-hydrazobenothiazol (1), which was condensed with various aromatic aldehydes.
Azomethine derivatives (2a–c) are converted into a number of 4-oxothiazolidines (3a–c) and tetrazole derivatives (4a–c), through the reaction of azomethine derivatives (2a–c) with mercaptoacetic acid and sodium azide, respectively.
Also the reaction of compound (1) with triethylorthoformate and nitrous acid to produce the corresponding (triazole and tetrazole) benzothiazole (5,6) was reported.
Triazole moieties reported condensation (MBT) with ethylbromo acetate and potassium hydroxide by the fusion method and resulted in ester-2-mercaptobenzothiazole (7), which was treated with hydrazine hydrate to give a hydrazine derivative (8), then converting these compounds (8) to phenyl semicarbazide (9) and phenyl thiosemicarbazide (10) derivatives.
Cyclization compounds (9,10) in alkaline media (4 NÆNaOH) gave triazoles compounds (11,12).
Furthermore the compound (8) was converted to the dithiocarbazate salt (13) which was then cyclized with hydrazine hydrate to give substituted triazole (14).
The prepared compounds were identified by spectral methods (FTIR, 1H NMR, 13C NMR) and some of its physical properties were measured and furthermore the effects of the preparing compounds on some strains of bacteria were studied.
American Psychological Association (APA)
al-Majdi, Suad M. H.. 2014. Synthesis of some new 4-oxo-thiazolidines, tetrazole and triazole derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized. Journal of Saudi Chemical Society،Vol. 18, no. 6, pp.893-901.
https://search.emarefa.net/detail/BIM-426711
Modern Language Association (MLA)
al-Majdi, Suad M. H.. Synthesis of some new 4-oxo-thiazolidines, tetrazole and triazole derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized. Journal of Saudi Chemical Society Vol. 18, no. 6 (2014), pp.893-901.
https://search.emarefa.net/detail/BIM-426711
American Medical Association (AMA)
al-Majdi, Suad M. H.. Synthesis of some new 4-oxo-thiazolidines, tetrazole and triazole derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 6, pp.893-901.
https://search.emarefa.net/detail/BIM-426711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 900-901
Record ID
BIM-426711