Flavonoid constituents, cytotoxic and antioxidant activities of Gleditsia triacanthos L. leaves
Joint Authors
Muhammad, R. S.
Abou Zeid, A. H.
al-Hawwari, S. S.
Salim, A. A.
Ashur, W. E.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 21, Issue 6 (31 Dec. 2014), pp.547-553, 7 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Gleditsia triacanthos L.
is a deciduous tree belonging to the family Fabaceae.
It possesses important biological activities as anti-mutagenic, anticancer, cytotoxic and treating rheumatoid arthritis.
The total ethanol extract (EtOHE) and successive extracts (petroleum ether, chloroform, ethyl acetate, and aqueous ethanol) were prepared from the leaves.
Eight flavone glycosides and two flavone aglycones named vicenin-I (1), vitexin (2), isovitexin (3), orientin (4), isoorientin (5), luteolin-7-O-ك-glucopyranoside (6), luteolin-7-O-ك-galactopyranoside (7), apigenin-7-O-ك-glucopyranoside (8), luteolin (9) and apigenin (10) were isolated from the aqueous ethanol extract of G.
triacanthos L.
leaves.
Potent cytotoxic activity of the EtOHE extract was observed against the liver (IC50 = 1.68 lg), breast (IC50 = 0.74 lg), cervix (IC50 = 1.28 lg), larynx (IC50 = 0.67 lg) and colon (IC50 = 2.50 lg) cancer cell lines.
Cytotoxic activity of compounds 2, 4, 6 and 8 against, the liver, breast and colon cancer cell lines was also proved.
Evaluation of the in-vivo antioxidant activity of the EtOHE and successive extracts revealed that the highest activity was exhibited by 100 mg of EtOHE (97.89 % potency) as compared with vitamin E (100 % potency).
Compound 6 showed 91.8% free radical scavenging activity.
American Psychological Association (APA)
Muhammad, R. S.& Abou Zeid, A. H.& al-Hawwari, S. S.& Salim, A. A.& Ashur, W. E.. 2014. Flavonoid constituents, cytotoxic and antioxidant activities of Gleditsia triacanthos L. leaves. Saudi Journal of Biological Sciences،Vol. 21, no. 6, pp.547-553.
https://search.emarefa.net/detail/BIM-427730
Modern Language Association (MLA)
Muhammad, R. S.…[et al.]. Flavonoid constituents, cytotoxic and antioxidant activities of Gleditsia triacanthos L. leaves. Saudi Journal of Biological Sciences Vol. 21, no. 6 (Dec. 2014), pp.547-553.
https://search.emarefa.net/detail/BIM-427730
American Medical Association (AMA)
Muhammad, R. S.& Abou Zeid, A. H.& al-Hawwari, S. S.& Salim, A. A.& Ashur, W. E.. Flavonoid constituents, cytotoxic and antioxidant activities of Gleditsia triacanthos L. leaves. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 6, pp.547-553.
https://search.emarefa.net/detail/BIM-427730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 553
Record ID
BIM-427730