Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women
Author
Source
Saudi Journal of Biological Sciences
Issue
Vol. 21, Issue 6 (31 Dec. 2014), pp.610-615, 6 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Genome-wide association studies have identified loci that are firmly associated with obesity.
The Src-homology-2 B adaptor protein 1 (SH2B1) loci is abundantly expressed in the brain, liver, heart, muscle, and fat tissues.
Gestational diabetes mellitus (GDM) is a growing health concern that usually appears during the latter half of pregnancy, and it is characterized by carbohydrate intolerance of variable severity.
The SH2B1 gene polymorphism has been linked with an increased risk of weight gain in several but not all population studies.
This study aimed to investigate the genetic association of rs4788102 variants in the SH2B1 gene with GDM in Saudi pregnant women.
Genomic DNA samples from 200 women with GDM and 300 women without GDM were genotyped using the TaqMan method.
The distribution of the GG, GA, and AA genotypes was significantly different between GDM and non-GDM women (p < 0.05).
Thus, we identified rs4788102 variants as additional risk factors for GDM in Saudi women, and we suggest that these variants may have a prognostic value.
American Psychological Association (APA)
al-Hakim, Malak Muhammad. 2014. Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women. Saudi Journal of Biological Sciences،Vol. 21, no. 6, pp.610-615.
https://search.emarefa.net/detail/BIM-427866
Modern Language Association (MLA)
al-Hakim, Malak Muhammad. Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women. Saudi Journal of Biological Sciences Vol. 21, no. 6 (Dec. 2014), pp.610-615.
https://search.emarefa.net/detail/BIM-427866
American Medical Association (AMA)
al-Hakim, Malak Muhammad. Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 6, pp.610-615.
https://search.emarefa.net/detail/BIM-427866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 614-615
Record ID
BIM-427866