Preventive effect of intrathecal paracetamol on spinal cord injury in rats
Joint Authors
Peker, Kemal
Sahin, Murat
Sayar, Ilyas
Gullu, Huriye
Yildiz, Husayn
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 11 (30 Nov. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-11-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Ischemic injury of the spinal cord during the surgical repair of thoracoabdominal aortic aneurysms might lead to paraplegia.
Although a number of different mechanisms have been proposed, the exact cause of paraplegia has remained unknown, hampering the development of effective pharmacologic or other strategies for prevention of this condition.
A number of studies suggested that cyclooxygenases (COX) contribute to neural breakdown ; thus, COX inhibitors might reduce injury.
Objectives : We aimed to assess the preventive effect of intrathecal (IT) pretreatment with paracetamol on spinal cord injury in a rat model.
Materials and Methods : This experimental study was performed in Ataturk University Animal Research Laboratory Center, Erzurum, Turkey.
Adult male Wistar rats were randomly allocated to three experimental groups (n = 6) to receive IT physiologic saline (controls), 50 μg of paracetamol, or 100 μg paracetamol one hour before induction of spinal cord ischemia.
Six other rats were considered as the sham group.
For the assessment of ischemic injury, motor functions of the hind limbs and histopathologic changes of the lumbar spinal cord were evaluated.
Additional 20 rats were divided into two equal groups for the second part of the study where the survival rates were recorded in controls and in animals receiving 100 μg of paracetamol during the 28-day observation period.
Results : Pretreatment with 100 μg of paracetamol resulted in a significant improvement in motor functions and histopathologic findings (P < 0.05).
Despite a higher rate of survival in 100 μg of paracetamol group (70 %) at day 28, the difference was not statistically significant in comparison with controls.
Conclusions : Our results suggest a protective effect of pretreatment with IT paracetamol on ischemic spinal cord injury during thoracolumbar aortic aneurysm surgery.
American Psychological Association (APA)
Sahin, Murat& Sayar, Ilyas& Peker, Kemal& Gullu, Huriye& Yildiz, Husayn. 2014. Preventive effect of intrathecal paracetamol on spinal cord injury in rats. Iranian Red Crescent Medical Journal،Vol. 16, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-427944
Modern Language Association (MLA)
Sahin, Murat…[et al.]. Preventive effect of intrathecal paracetamol on spinal cord injury in rats. Iranian Red Crescent Medical Journal Vol. 16, no. 11 (Nov. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-427944
American Medical Association (AMA)
Sahin, Murat& Sayar, Ilyas& Peker, Kemal& Gullu, Huriye& Yildiz, Husayn. Preventive effect of intrathecal paracetamol on spinal cord injury in rats. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-427944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-427944