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E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions
Joint Authors
Muhammad, Iman Muhammad Salah al-Din
Ahmad, Ahmad R. H.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 26, Issue 4 (31 Dec. 2014), pp.211-217, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Loss of E-cadherin is a critical step for development and progression of malignant tumors.
CD10 ; a marker of non-neoplastic and neoplastic endometrial stroma, is associated with aggressiveness of many epithelial malignancies.
Aims : To evaluate expression and correlation of E-cadherin and CD10 in endometrial lesions and their possible role in differentiating atypical endometrial hyperplasia from endometrial carcinoma.
The association of E-cadherin and CD10 expression with clinico-pathological parameters of endometrial carcinoma was also investigated.
Materials and methods : Fifty four cases including 28 endometrial carcinomas ; 19 endometrial hyperplasia and 7 cases of normal endometrial changes were enrolled for this study.
The expression of E-cadherin and CD10 was evaluated by immunohistochemistry using the streptavidin-biotintechnique.
Results : There was a strong association between malignant change of endometrial glands and membrano- cytoplasmic localization of E-cadherin (p < 0.001).
Expression of E-cadherin but not CD10 was significantly higher in endometrial carcinomas compared to atypical endometrial hyperplasia (p < 0.01).
Expression of E-cadherin was not associated with CD10 expression in different endometrial lesions.
High grade tumors expressed low levels of both E-cadherin (p < 0.01) and CD10 (p < 0.05) and serous endometrial carcinoma had low E-cadherin and CD10 expression compared to endometrioid carcinoma (p < 0.01 and < 0.05, respectively).
Expression of both molecules showed no association with depth of tumor invasion or FIGO stage.
Tumors with lower E-cadherin or CD10 expression had higher rates of vascular tumor emboli (p < 0.01 and < 0.07, respectively).
Conclusions : Although expression of E-cadherin and CD10 in endometrial lesions was not correlated, reduced expression of both molecules could be critical for progression of endometrial carcinoma.
American Psychological Association (APA)
Ahmad, Ahmad R. H.& Muhammad, Iman Muhammad Salah al-Din. 2014. E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 4, pp.211-217.
https://search.emarefa.net/detail/BIM-428612
Modern Language Association (MLA)
Ahmad, Ahmad R. H.& Muhammad, Iman Muhammad Salah al-Din. E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions. Journal of the Egyptian National Cancer Institute Vol. 26, no. 4 ( 2014), pp.211-217.
https://search.emarefa.net/detail/BIM-428612
American Medical Association (AMA)
Ahmad, Ahmad R. H.& Muhammad, Iman Muhammad Salah al-Din. E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 4, pp.211-217.
https://search.emarefa.net/detail/BIM-428612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 216-217
Record ID
BIM-428612