The prognostic value of triple negative in stage 11 111 breast cancer

Abstract EN

Introduction : Breast cancer is no longer seen as a single disease but rather a multifaceted disease composed of distinct biological subtypes with diverse natural history, clinical, pathological and molecular features.

Recent attention has been directed at molecular classification of breast cancer.

Objective : To evaluate the prognostic value of triple negative subtype in stage 11 / 111 breast cancer.

To define the role of clinical stage in prognosis of breast cancer Methods : We used immuno- histochemical technique to divide 255 cases of breast cancer, stages II and III into four subtypes according to estrogen receptor / progesterone receptor (ER / PRj and Iler-2 expression.

Results : Triple-negative subtype comprised 76.5 % of the cases with 12.3 % recurrence rate.

Luminal A subtype also carried a poor out come with 16.7 % recurrence rate.

Conclusion : Triple negative subtype has the worst overall and disease-free survival in stage ITIII breast cancer.

Clinical stage is still an independent prognostic factor in breast cancer of all types.