Evaluation of rifaximin in management of hepatic encephalopathy
Joint Authors
Salim, M. Najm al-Din
al-Dasuqi, Yasir M. M.
Wahib, Ali A.
Ahmad, Mustafa A.
al-Tiby, Diya M.
al-Mawla, Khalid
al-Sayyid, Abir M.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 44, Issue 3 (31 Dec. 2014), pp.677-685, 9 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study evaluated the efficacy of rifaximin versus lactulose in the treatment of hepatic encephalopathy (HE).
The study population included 50 patients who were diagnosed to have signs of the first to third degree HE, according to the West Haven criteria and classified into two groups.
GI : included 25 patients who had HE and were treated with lactulose syrup (laxolac) 90 ml daily divided into 3 doses for 7 days.
GII: included 25 patients who had HE and were treated with rifaximin 1200 mg daily divided into 3 doses for 7 days.
Patients in both groups also received other measures of treatment of HE as daily enema and protein restriction.\ Rifaximin significantly improved various subjective and measurable components of HE including mental status, behavior, asterixis, and serum ammonia concentration.
In acute HE of grade 1 to grade 3, rifaximin may be a good alternative to non-absorbable isaccharides as it is broad spectrum, non-absorbable antibiotic with rapid action and little side effects.
It is better tolerated, associated with less frequent and shorter hospitalization in comparison to lactulose.
American Psychological Association (APA)
Wahib, Ali A.& Salim, M. Najm al-Din& Ahmad, Mustafa A.& al-Dasuqi, Yasir M. M.& al-Tiby, Diya M.& al-Mawla, Khalid…[et al.]. 2014. Evaluation of rifaximin in management of hepatic encephalopathy. Journal of the Egyptian Society of Parasitology،Vol. 44, no. 3, pp.677-685.
https://search.emarefa.net/detail/BIM-431031
Modern Language Association (MLA)
Wahib, Ali A.…[et al.]. Evaluation of rifaximin in management of hepatic encephalopathy. Journal of the Egyptian Society of Parasitology Vol. 44, no. 3 (Dec. 2014), pp.677-685.
https://search.emarefa.net/detail/BIM-431031
American Medical Association (AMA)
Wahib, Ali A.& Salim, M. Najm al-Din& Ahmad, Mustafa A.& al-Dasuqi, Yasir M. M.& al-Tiby, Diya M.& al-Mawla, Khalid…[et al.]. Evaluation of rifaximin in management of hepatic encephalopathy. Journal of the Egyptian Society of Parasitology. 2014. Vol. 44, no. 3, pp.677-685.
https://search.emarefa.net/detail/BIM-431031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 684-685
Record ID
BIM-431031