Follow-up study of post-infectious glomerulonephritis in adults : analysis of predictors of poor renal outcome
Joint Authors
Balasubramaniyan, T.
Natarajan, Gopalakrishnan
Ramanathan, Sakthirajan
Jeyachandran, Dhanapriya
Srinivasa Prasad N. D.
Thanigachalam, Dineshkumar
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 6 (31 Dec. 2014), pp.1210-1216, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Post-infectious glomerulonephritis (PIGN) still remains one of the most common glomerulonephritis in the developing world.
We studied the epidemiology and clinical spectrum of PIGN in adults to identify the clinical, biochemical and histological factors that would predict renal outcome.
Data of 102 adult PIGN patients treated between 2009 and 2011 with a mean follow- up of 12 months (6–36 months) were analyzed retrospectively.
The mean age of the patients was 32.7 ± 15 years, with a male to female ratio of 1.2 : 1.
At presentation, 99% of the patients had edema and oliguria, 73 % had hypertension, 55 % had macrohematuria and 60 % had nephrotic range proteinuria.
About 14 % presented with complications (pulmonary edema-6 %, seizure-1 %, dialysis requiring renal failure-7 %) and 9 % had co-morbid illness.
Sixty percent of the patients had serum creatinine > 2 mg / dL at presentation, which was persistent in 30 % at the end of one week and 68 % had hypo-complementemia.
Renal biopsy revealed diffuse proliferative glomerulonephritis in 70 % of the patients.
At 12 months, 2 % had persistent hypertension, 10 % had persistent proteinuria and hematuria and 11 % had serum creatinine > 1.5 mg / dL.
Univariate analysis with the Fischer Exact test revealed age > 40 years, male gender, serum creatinine > 2 mg / dL at one week, co-morbid illness, requirement of dialysis, crescents in > 30 % glomeruli and persistent proteinuria and microscopic hematuria at 12 months as significant risk factors for poor renal outcome.
Serum creatinine > 2 mg / dL at one week and persistent proteinuria at 12 months were the independent risk factors that predicted poor renal outcome at one year.
American Psychological Association (APA)
Natarajan, Gopalakrishnan& Ramanathan, Sakthirajan& Jeyachandran, Dhanapriya& Balasubramaniyan, T.& Srinivasa Prasad N. D.& Thanigachalam, Dineshkumar. 2014. Follow-up study of post-infectious glomerulonephritis in adults : analysis of predictors of poor renal outcome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 6, pp.1210-1216.
https://search.emarefa.net/detail/BIM-431628
Modern Language Association (MLA)
Natarajan, Gopalakrishnan…[et al.]. Follow-up study of post-infectious glomerulonephritis in adults : analysis of predictors of poor renal outcome. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 6 (Dec. 2014), pp.1210-1216.
https://search.emarefa.net/detail/BIM-431628
American Medical Association (AMA)
Natarajan, Gopalakrishnan& Ramanathan, Sakthirajan& Jeyachandran, Dhanapriya& Balasubramaniyan, T.& Srinivasa Prasad N. D.& Thanigachalam, Dineshkumar. Follow-up study of post-infectious glomerulonephritis in adults : analysis of predictors of poor renal outcome. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 6, pp.1210-1216.
https://search.emarefa.net/detail/BIM-431628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1215-1216
Record ID
BIM-431628