Performance of QuantiFERON TB gold test in detecting latent tuberculosis infection in brain-dead organ donors in Iran : a brief report
Joint Authors
Tabarsi, Payam
Yousefzadeh, Amir
Droudinia, Atousa
Bayati, Rouzbeh
Marjani, Majid
Shafaghi, Shadi
Farokhzad, Banafsheh
Javanmard, Pedram
Velayati, Ali Akbar
Najafizadeh, Katayoun
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 6 (31 Dec. 2014), pp.1240-1243, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
With regard to the significant morbidity and mortality due to tuberculosis in lung transplant recipients, the identification of brain-dead organ donors with latent tuberculosis by use of the QuantiFERON TB Gold (QFT-G) test may be of help to reduce the risk of TB reactivation and mortality in lung recipients.
This study was conducted in the National Research Institute of Tuberculosis and Lung Diseases (NRITLD) in Iran, from January to March 2013.
A total of 38 consecutive brain-dead donors, not currently infected with active tuberculosis, were recruited.
The medical records of all the study enrollees were reviewed.
A whole-blood IFN-γ release assay (IGRA) in reaction to early secreted antigenic target 6 (ESAT-6), culture filtrate protein 10 (CFP-10), and TB7.7 antigens, was performed and the released Interferon-γ was measured via enzyme-linked immunosorbent assay (ELISA).
The data was analyzed with QFT-G software which was provided by the company.
The demographic, characteristics and other variables were entered into SPSS version 11.5.
The QFT-G test results of three donors (7.9 %) turned out to be positive, negative for 24 donors (63.1 %), and indeterminate for 11 cases (28.9 %).
Our study revealed the potential advantages of QFT-G in lowering the incidence of donor-derived post-transplant tuberculosis among lung recipients.
However, a high rate of indeterminate results restricted the performance of QFT-G in this study.
American Psychological Association (APA)
Tabarsi, Payam& Yousefzadeh, Amir& Najafizadeh, Katayoun& Droudinia, Atousa& Bayati, Rouzbeh& Marjani, Majid…[et al.]. 2014. Performance of QuantiFERON TB gold test in detecting latent tuberculosis infection in brain-dead organ donors in Iran : a brief report. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 6, pp.1240-1243.
https://search.emarefa.net/detail/BIM-431682
Modern Language Association (MLA)
Tabarsi, Payam…[et al.]. Performance of QuantiFERON TB gold test in detecting latent tuberculosis infection in brain-dead organ donors in Iran : a brief report. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 6 (Dec. 2014), pp.1240-1243.
https://search.emarefa.net/detail/BIM-431682
American Medical Association (AMA)
Tabarsi, Payam& Yousefzadeh, Amir& Najafizadeh, Katayoun& Droudinia, Atousa& Bayati, Rouzbeh& Marjani, Majid…[et al.]. Performance of QuantiFERON TB gold test in detecting latent tuberculosis infection in brain-dead organ donors in Iran : a brief report. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 6, pp.1240-1243.
https://search.emarefa.net/detail/BIM-431682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1243
Record ID
BIM-431682