The application of immunohisto chemical markers for diagnosis, classification and grading of neuroendocrine tumors

Abstract EN

Objectives : To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors .

Methodology : This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January-October 2013.

A total of 50 patients with neuroendocrine tumors from different locations.

Their ages ranging between 22-80 years with a mean age of 48.3 years.

Two step Envision TM flex method was employed for immunhis to chemical detection of ki67 antigen (MIB -1) and Chromogranin A.

Results : Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance, from 50 patients 44 (88 %) cases was positive for Chromoranin A expression, there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value > 0.05).

Conclusion : Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade.

Recommendation : We advise to use Chromogranin A immune his to chemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy.