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Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus : correlation with SLEDAI score and disease activity parameters
Joint Authors
Abu al-Futuh, Sahar
Muhammad, Rim Hamdi A.
Abu Zayd, Hanan S. Muhammad
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 41, Issue 4 (31 Dec. 2014), pp.160-166, 7 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Aim : The aim of the study was to assess serum levels of interleukin (IL)-18 and IL-10 in systemic lupus erythematosus (SLE) patients and their relationship with disease activity.
Patients and methods : Thirty patients with SLE and 20 healthy controls were investigated in this study.
The serum IL-18 and IL-10 levels were determined using enzyme-linked immunosorbent assay and their correlations with the disease activity were measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and laboratory parameters, including erythrocyte sedimentation rate, anti-ds DNA antibody, complement 3, and complement 4 levels were analyzed.
Results : The serum IL-18 and serum IL-10 levels were significantly higher (mean values 1770.2 ± 360.4 and 842.65 ± 315.37 pg / ml for IL-18 and IL-10, respectively) in SLE patients compared with the controls (110.65 ± 30.37 vs.
76 ± 14.2 pg / ml, respectively, P < 0.001).
The increase in serum levels of IL-18 and IL-10 directly and significantly correlated with each other (r = 0.404, P = 0.037).
Furthermore, such an increase in the levels of these two cytokines showed a highly significant positive correlation with the SLEDAI scores and anti-ds DNA in the studied patients (P < 0.001).
Conclusion : The circulating IL-18 and IL-10 concentrations were significantly elevated in SLE patients and correlated with the SLEDAI score.
The study emphasized that there exists an upregulated proinflammatory as well as anti-inflammatory responses in patients with active SLE ; however, the anti-inflammatory response is not enough to suppress the active disease.
Identifying the exact contribution of the currently studied cytokines might provide future insights for targeted therapeutic strategies in SLE.
American Psychological Association (APA)
Abu al-Futuh, Sahar& Muhammad, Rim Hamdi A.& Abu Zayd, Hanan S. Muhammad. 2014. Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus : correlation with SLEDAI score and disease activity parameters. Egyptian Rheumatology and Rehabilitation،Vol. 41, no. 4, pp.160-166.
https://search.emarefa.net/detail/BIM-435668
Modern Language Association (MLA)
Abu Zayd, Hanan S. Muhammad…[et al.]. Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus : correlation with SLEDAI score and disease activity parameters. Egyptian Rheumatology and Rehabilitation Vol. 41, no. 4 (2014), pp.160-166.
https://search.emarefa.net/detail/BIM-435668
American Medical Association (AMA)
Abu al-Futuh, Sahar& Muhammad, Rim Hamdi A.& Abu Zayd, Hanan S. Muhammad. Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus : correlation with SLEDAI score and disease activity parameters. Egyptian Rheumatology and Rehabilitation. 2014. Vol. 41, no. 4, pp.160-166.
https://search.emarefa.net/detail/BIM-435668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 165-166
Record ID
BIM-435668