Studies on the role of goat heart galectin-1 as a tool for detecting post-malignant changes in glycosylation pattern
Joint Authors
Kamal, Muhammad A.
Ashraf, Ghulam Md
Tabrez, Shams
Perveen, Asma
Zaydi, Sayyid Kashif
Bani, Nahid
Source
Saudi Journal of Biological Sciences
Issue
Vol. 22, Issue 1 (31 Mar. 2015), pp.85-89, 5 p.
Publisher
Publication Date
2015-03-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Galectins are mammalian lectins established to play a crucial role in the progression of various cancer types by the virtue of their differential expression in normal and cancerous cells.
In the present study, goat heart galectin-1 (GHG-1) was purified and investigated for its potential role in the detection of post-malignant changes in glycosylation pattern.
When exposed to superoxide radicals generated from a pyrogallol auto-oxidation system, GHG-1 treated erythrocyte suspension released higher amount of oxyhemoglobin than the unagglutinated erythrocytes.
The extent of erythrocyte hemolysis was found to be directly proportional to concentrations of hypochlorous acid.
GHG-1 was used to detect the change in the b-galactoside expression pattern in erythrocyte membrane from human donors suffering from prostate and breast cancer.
No significant change was observed in the hemolysis of lectin agglutinated erythrocytes collected from pre-operated breast cancer patients, whereas significant increase was observed in normal healthy control and postoperated samples.
Findings of this study proclaim GHG-1 as an important tool for the detection of post-malignant changes in glycosylation pattern.
American Psychological Association (APA)
Ashraf, Ghulam Md& Perveen, Asma& Tabrez, Shams& Zaydi, Sayyid Kashif& Kamal, Muhammad A.& Bani, Nahid. 2015. Studies on the role of goat heart galectin-1 as a tool for detecting post-malignant changes in glycosylation pattern. Saudi Journal of Biological Sciences،Vol. 22, no. 1, pp.85-89.
https://search.emarefa.net/detail/BIM-437362
Modern Language Association (MLA)
Ashraf, Ghulam Md…[et al.]. Studies on the role of goat heart galectin-1 as a tool for detecting post-malignant changes in glycosylation pattern. Saudi Journal of Biological Sciences Vol. 22, no. 1 (2015), pp.85-89.
https://search.emarefa.net/detail/BIM-437362
American Medical Association (AMA)
Ashraf, Ghulam Md& Perveen, Asma& Tabrez, Shams& Zaydi, Sayyid Kashif& Kamal, Muhammad A.& Bani, Nahid. Studies on the role of goat heart galectin-1 as a tool for detecting post-malignant changes in glycosylation pattern. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 1, pp.85-89.
https://search.emarefa.net/detail/BIM-437362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 88-89
Record ID
BIM-437362