Effects of guru (cola nitida)‎ on drug metabolizing enzymes in rats

Other Title(s)

تأثير القورو (كولا نيتيدا)‎ على نشاط إنزيمات الآيض الدوائية في الجرذان

Joint Authors

Muhammad, Uthman Sad Ali
Ahmad, Abd al-Baqi Mustafa
Hamidah, Muhammad Abd al-Qadir Musa

Source

Journal of Science and Technology : in Agricultural and Veterinary Sciences

Issue

Vol. 13, Issue 2 (31 Dec. 2012), pp.102-106, 5 p.

Publisher

Sudan University of Science and Technology Deanship of Scientific Research

Publication Date

2012-12-31

Country of Publication

Sudan

No. of Pages

5

Main Subjects

Veterinary Medicine

Topics

Abstract AR

لقد أجرى هذا البحث لدراسة تأثير القورو على نشاط أنزيمات أيض الأدوية في الفئران لمدة 28 يوما.

لقد أوضحت النتائج و بدلالة إحصائية إلى فعالية الجرعة 100 ملجرام للكيلو جرام إلى تحفيز نشاط أنزيمات الأكسدة الدوائية بينما تم تثبيط نشاط هذه الأنزيمات عند الجرعات 200, 400 ملجرام للكيلو جرام مقارنة بالشاهد تشير هذه النتائج إلى أن القورو في جرعات 100 ملجرام للكيلوجرام ربما كانت جرعات دوائية بينما الجرعات 200, 400 ملجرام للكيلوجرام هي جرعات سمية.

Abstract EN

The objective of this study was to investigate the effect of guru on drug metabolizing enzymes in rats.

Guru at a dose of 100 mg / kg administered orally to rats caused induction of hepatic microsmal mixed function oxidase, but at the dose of 200 and 400 mg / kg inhibited the drug metabolizing enzymes compared to controls that were given rat diet.

It is concluded that guru may produce pharmacological effects at the dose of 100 mg / kg and toxicological effects at higher doses.

American Psychological Association (APA)

Ahmad, Abd al-Baqi Mustafa& Muhammad, Uthman Sad Ali& Hamidah, Muhammad Abd al-Qadir Musa. 2012. Effects of guru (cola nitida) on drug metabolizing enzymes in rats. Journal of Science and Technology : in Agricultural and Veterinary Sciences،Vol. 13, no. 2, pp.102-106.
https://search.emarefa.net/detail/BIM-439650

Modern Language Association (MLA)

Ahmad, Abd al-Baqi Mustafa…[et al.]. Effects of guru (cola nitida) on drug metabolizing enzymes in rats. Journal of Science and Technology : in Agricultural and Veterinary Sciences Vol. 13, no. 2 (Dec. 2012), pp.102-106.
https://search.emarefa.net/detail/BIM-439650

American Medical Association (AMA)

Ahmad, Abd al-Baqi Mustafa& Muhammad, Uthman Sad Ali& Hamidah, Muhammad Abd al-Qadir Musa. Effects of guru (cola nitida) on drug metabolizing enzymes in rats. Journal of Science and Technology : in Agricultural and Veterinary Sciences. 2012. Vol. 13, no. 2, pp.102-106.
https://search.emarefa.net/detail/BIM-439650

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 104-105

Record ID

BIM-439650