Comparison of bypassing agents in bleeding reduction in treatment of bleeding episodes in patients with haemophilia and inhibitors
Joint Authors
Golestani, Mina
Eshghi, Peyman
Rasikh, Hamid Reza
Cheraghali, Abd al-Majid
Salamzadeh, Jamshid
Imani, Ali
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 12 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-12-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
- Social sciences
- Research
- Evaluation
- Psychometrics
- Statistics
- Medicine
- Blood
- Disorders
- Meta-analysis
- Coagulation
- Hemophilia
Abstract EN
Context : Mild-to-moderate bleeding disorders in haemophilia are primarily treated via recombinant activated factor VII a (rFVIIa) or activated prothrombin complex concentrate (aPCC).
However, the efficacy of each bypassing agents may vary and none of them is universally effective.
Evidence Acquisition: After reviewing the databases of PubMed, Scopus, MD Consult, Ovid, Trip database, Google Scholar, ProQuest and the Cochrane Library, finally, 17 papers published from 2000 to 2013 were extracted.
We used as a random effect model in meta-analysis.
Comprehensive meta-analysis (CMA) software was used for calculating and estimating the mean of bleeding reduction and performing meta-analysis.
Results : The mean of bleeding reduction in aPCC and rFVIIa were 71.2 % with CI 95 % (lower limit 86.8 % and upper limit 82 %) and 72.3 % with CI 95 % (lower limit 57.6 % and upper limit 83.4 %), respectively.
Conclusions: Although differences between the two products were very close to each other, they reported similar effects on joint bleeds.
Further clinical studies should be performed by incorporating a standardized measurement in comparative efficacy of aPCC and rFVIIa.
American Psychological Association (APA)
Golestani, Mina& Eshghi, Peyman& Rasikh, Hamid Reza& Cheraghali, Abd al-Majid& Salamzadeh, Jamshid& Imani, Ali. 2014. Comparison of bypassing agents in bleeding reduction in treatment of bleeding episodes in patients with haemophilia and inhibitors. Iranian Red Crescent Medical Journal،Vol. 16, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-441987
Modern Language Association (MLA)
Golestani, Mina…[et al.]. Comparison of bypassing agents in bleeding reduction in treatment of bleeding episodes in patients with haemophilia and inhibitors. Iranian Red Crescent Medical Journal Vol. 16, no. 12 (Dec. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-441987
American Medical Association (AMA)
Golestani, Mina& Eshghi, Peyman& Rasikh, Hamid Reza& Cheraghali, Abd al-Majid& Salamzadeh, Jamshid& Imani, Ali. Comparison of bypassing agents in bleeding reduction in treatment of bleeding episodes in patients with haemophilia and inhibitors. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-441987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-441987