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Relationship between asymmetric dimethylarginine plasma level and Left ventricular mass in hemodialysis patients
Joint Authors
al-Shahawy, Yasir
Madi, Jamal
Shinnawi, Huwayda
Buhayri, Maha
Rifai, Ahmad
Sulayman, Yasir
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 1 (28 Feb. 2015), pp.26-33, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-02-28
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
- Patients
- Heart
- Amino acids
- Hemodialysis
- Complications(Medicine)
- Kidney failure
- Left ventricular hypertrophy
Abstract EN
Left ventricular hypertrophy (LVH) and left ventricular dysfunction are highly prevalent in patients with end-stage renal disease (ESRD).
Several studies suggest that left ventricular mass and function is strongly modulated by the nitric oxide (NO) system.
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial-based NO synthase, is emerging as an important cardiovascular risk factor in ESRD patients.
Our objective is to evaluate the relationship between plasma ADMA level and LVH among hemodialysis (HD) patients.
Plasma ADMA measurements by enzyme-linked immunosorbent assay and chocardiographic evaluation were performed for 40 patients on regular HD, 20 patients with pre-dialysis chronic kidney disease, 20 hypertensive patients with left ventricular hypertrophy and normal kidney function and 20 healthy age- and sex-matched subjects as a control group.
Residual renal function (RRF) was measured in HD patients by urea clearance from a urine collection.
Mean values of plasma ADMA level were significantly high in all patient groups when compared with the control group (P < 0.001).
However, there was no significant difference between groups I, II and III as regards mean values of plasma ADMA (P > 0.05) and between ADMA and RRF in HD patients (r = -0.20, P = 0.60).
It was also seen that plasma ADMA was not correlated with left entricular mass index; however, there could be an association between ADMA level and diastolic dysfunction.
The plasma ADMA level was found to be high in the three studied patient groups in comparison with the control group.
HD is not an effective procedure for adequate removal of ADMA.
American Psychological Association (APA)
al-Shahawy, Yasir& Sulayman, Yasir& Rifai, Ahmad& Shinnawi, Huwayda& Buhayri, Maha& Madi, Jamal. 2015. Relationship between asymmetric dimethylarginine plasma level and Left ventricular mass in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 1, pp.26-33.
https://search.emarefa.net/detail/BIM-442400
Modern Language Association (MLA)
Rifai, Ahmad…[et al.]. Relationship between asymmetric dimethylarginine plasma level and Left ventricular mass in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 1 (Jan. / Feb. 2015), pp.26-33.
https://search.emarefa.net/detail/BIM-442400
American Medical Association (AMA)
al-Shahawy, Yasir& Sulayman, Yasir& Rifai, Ahmad& Shinnawi, Huwayda& Buhayri, Maha& Madi, Jamal. Relationship between asymmetric dimethylarginine plasma level and Left ventricular mass in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 1, pp.26-33.
https://search.emarefa.net/detail/BIM-442400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 32-33
Record ID
BIM-442400