Association of early atheroselerotic vascular changes with serum lipoprotien (a) in pre-dialysis chronic renal failure and maintenance hemodialysis patients
Joint Authors
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 16, Issue 2 (30 Apr. 2005), pp.154-160, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2005-04-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Heart
- Kidneys
- Diseases
- Chronic diseases
- Coronary heart diseases
- Therapeutics
- Hemodialysis
- Blood
- Complications(Medicine)
- Kidney failure
- Atherosclerosis
Abstract EN
Elevated plasma lipoprotein (LPa) level in chronic renal failure patients is recognized as an independent risk factor for premature atherosclerotic coronary heart disease.
In this cross-sectional study we aimed to study the effect of serum plasma LPa levels on early structural atherosclerotic vascular changes in chronic renal failure (CRF) predialysis and hemodialysis (HD) populations.
We evaluated the carotid intima-media thickness and carotid-femoral artery for plaque occurrence (plaque score) by B-mode ultrasonography in 29 (17F, 12M) normal subjects (group one), 33 (19F, 14M) CRF predialysis patients (group 2) and 43 (19F, 24M) HD patients (group 3).
The Mean LPa in group 1,2 and 3 were 42.0 ± 20.0, 57.0 ± 23.0 and 55.0 ± 16.0 mg / dl, respectively (p=0.016).
The Intimae- media thickness (IMT) of group 1, 2 and 3 was 0.84 ± 0.20 1.30 ± 0.40 and 1.10 ± 0.30 mm, respectively (p<0.001).
Plaque scores between 1 and 2 were found in 6.8% of the subjects in group 1, 24.3% in group 2 and 25.6% in group 3 (p<0.001).
Furthermore, plaque scores of 3 and 4 were found in no subjects in group 1, 36.4% in group 2 and 23.3% in group 3.
In conclusion ; the present study showed positive relationship of LPa with IMT and arterial plaque in HD patients but not the CRF patients.
However, accelerated atherosclerosis is frequently seen in these patients and larger clinical studies of this problem are needed.
American Psychological Association (APA)
Nasri, Hamid& Baradaran, Azar. 2005. Association of early atheroselerotic vascular changes with serum lipoprotien (a) in pre-dialysis chronic renal failure and maintenance hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 16, no. 2, pp.154-160.
https://search.emarefa.net/detail/BIM-44450
Modern Language Association (MLA)
Nasri, Hamid& Baradaran, Azar. Association of early atheroselerotic vascular changes with serum lipoprotien (a) in pre-dialysis chronic renal failure and maintenance hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 16, no. 2 (Dec. 2005), pp.154-160.
https://search.emarefa.net/detail/BIM-44450
American Medical Association (AMA)
Nasri, Hamid& Baradaran, Azar. Association of early atheroselerotic vascular changes with serum lipoprotien (a) in pre-dialysis chronic renal failure and maintenance hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2005. Vol. 16, no. 2, pp.154-160.
https://search.emarefa.net/detail/BIM-44450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 159-160
Record ID
BIM-44450