Antimicrobial Resistance Pattern and Their Beta-Lactamase Encoding Genes among Pseudomonas aeruginosa Strains Isolated from Cancer Patients
Joint Authors
al-Agamy, Mohamed H.
Amin, Magdy A.
Ashour, Mohammed Seif El-Din
Zafer, Mai M.
El-Mahallawy, Hadir A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was designed to investigate the prevalence of metallo-β-lactamases (MBL) and extended-spectrum β-lactamases (ESBL) in P.
aeruginosa isolates collected from two different hospitals in Cairo, Egypt.
Antibiotic susceptibility testing and phenotypic screening for ESBLs and MBLs were performed on 122 P.
aeruginosa isolates collected in the period from January 2011 to March 2012.
MICs were determined.
ESBLs and MBLs genes were sought by PCR.
The resistant rate to imipenem was 39.34%.
The resistance rates for P.
aeruginosa to cefuroxime, cefoperazone, ceftazidime, aztreonam, and piperacillin/tazobactam were 87.7%, 80.3%, 60.6%, 45.1%, and 25.4%, respectively.
Out of 122 P.
aeruginosa, 27% and 7.4% were MBL and ESBL, respectively.
The prevalence of blaVIM-2, blaOXA-10-, blaVEB-1, blaNDM-, and blaIMP-1-like genes were found in 58.3%, 41.7%, 10.4%, 4.2%, and 2.1%, respectively.
GIM-, SPM-, SIM-, and OXA-2-like genes were not detected in this study.
OXA-10-like gene was concomitant with VIM-2 and/or VEB.
Twelve isolates harbored both OXA-10 and VIM-2; two isolates carried both OXA-10 and VEB.
Only one strain contained OXA-10, VIM-2, and VEB.
In conclusion, blaVIM-2- and blaOXA-10-like genes were the most prevalent genes in P.
aeruginosa in Egypt.
To our knowledge, this is the first report of blaVIM-2, blaIMP-1, blaNDM, and blaOXA-10 in P.
aeruginosa in Egypt.
American Psychological Association (APA)
Zafer, Mai M.& al-Agamy, Mohamed H.& El-Mahallawy, Hadir A.& Amin, Magdy A.& Ashour, Mohammed Seif El-Din. 2014. Antimicrobial Resistance Pattern and Their Beta-Lactamase Encoding Genes among Pseudomonas aeruginosa Strains Isolated from Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-446387
Modern Language Association (MLA)
Zafer, Mai M.…[et al.]. Antimicrobial Resistance Pattern and Their Beta-Lactamase Encoding Genes among Pseudomonas aeruginosa Strains Isolated from Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-446387
American Medical Association (AMA)
Zafer, Mai M.& al-Agamy, Mohamed H.& El-Mahallawy, Hadir A.& Amin, Magdy A.& Ashour, Mohammed Seif El-Din. Antimicrobial Resistance Pattern and Their Beta-Lactamase Encoding Genes among Pseudomonas aeruginosa Strains Isolated from Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-446387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446387