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Metallothionein as an Anti-Inflammatory Mediator
Joint Authors
Shimada, Akinori
Satoh, Masahiko
Inoue, Ken-ichiro
Takano, Hirohisa
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes.
MT expression is induced/enhanced in various tissues by a number of physiological mediators.
The cellular accumulation of MT depends on the availability of cellular zinc derived from the diet.
MT modulates the binding and exchange/transport of heavy metals such as zinc, cadmium, or copper under physiological conditions and cytoprotection from their toxicities, and the release of gaseous mediators such as hydroxyl radicals or nitric oxide.
In addition, MT reportedly affects a number of cellular processes, such as gene expression, apoptosis, proliferation, and differentiation.
Given the genetic approach, the apparently healthy status of MT-deficient mice argues against an essential biological role for MT; however, this molecule may be critical in cells/tissues/organs in times of stress, since MT expression is also evoked/enhanced by various stresses.
In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied.
Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases.
In this paper, we review the role of MT of various inflammatory conditions.
American Psychological Association (APA)
Inoue, Ken-ichiro& Takano, Hirohisa& Shimada, Akinori& Satoh, Masahiko. 2009. Metallothionein as an Anti-Inflammatory Mediator. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-446390
Modern Language Association (MLA)
Inoue, Ken-ichiro…[et al.]. Metallothionein as an Anti-Inflammatory Mediator. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-446390
American Medical Association (AMA)
Inoue, Ken-ichiro& Takano, Hirohisa& Shimada, Akinori& Satoh, Masahiko. Metallothionein as an Anti-Inflammatory Mediator. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-446390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446390