Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells
Joint Authors
Zheng, Meizhu
Zeng, Yili
Pan, Jingxin
Huang, Qinmiao
Guo, Jianxin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study explored the effects of reactive nitrogen metabolites (RNMS) on natural-killer- (NK-) cell-mediated killing of K562 cells and the influence of RNM scavengers, such as tiopronin (TIP), glutamylcysteinylglycine (GSH), and histamine dihydrochloride (DHT), on reversing the suppressing effect of RNM.
We administered exogenous and endogenous RNM in the NK + K562 culture system and then added RNM scavengers.
The concentrations of RNM, TNF-β and IFN-γ, and NK-cell cytotoxicity (NCC) and the percentage of living NK cells were then examined.
We found that both exogenous and endogenous RNM caused the KIR to decrease (P<0.01); however, RNM scavengers such as TIP and GSH rescued this phenomenon dose dependently.
In conclusion, our data suggests that RNM scavengers such as TIP and GSH enhance the antineoplasmic activity of NK cells.
American Psychological Association (APA)
Zeng, Yili& Huang, Qinmiao& Zheng, Meizhu& Guo, Jianxin& Pan, Jingxin. 2012. Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446397
Modern Language Association (MLA)
Zeng, Yili…[et al.]. Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-446397
American Medical Association (AMA)
Zeng, Yili& Huang, Qinmiao& Zheng, Meizhu& Guo, Jianxin& Pan, Jingxin. Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446397