Clinical Trials and Treatment of ATL
Joint Authors
Tobinai, Kensei
Tsukasaki, Kunihiro
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
ATL is a distinct peripheral T-lymphocytic malignancy associated with human T-cell lymphotropic virus type I (HTLV-1).
The diversity in clinical features and prognosis of patients with this disease has led to its subtype-classification into four categories, acute, lymphoma, chronic, and smoldering types, defined by organ involvement, and LDH and calcium values.
In case of acute, lymphoma, or unfavorable chronic subtypes (aggressive ATL), intensive chemotherapy like the LSG15 regimen (VCAP-AMP-VECP) is usually recommended if outside of clinical trials, based on the results of a phase 3 trial.
In case of favorable chronic or smoldering ATL (indolent ATL), watchful waiting until disease progression has been recommended, although the long-term prognosis was inferior to those of, for instance, chronic lymphoid leukemia.
Retrospective analysis suggested that the combination of interferon alpha and zidovudine was apparently promising for the treatment of ATL, especially for types with leukemic manifestation.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is also promising for the treatment of aggressive ATL possibly reflecting graft versus ATL effect.
Several new agent trials for ATL are ongoing and in preparation, including a defucosylated humanized anti-CC chemokine receptor 4 monoclonal antibody, IL2-fused with diphtheria toxin, histone deacetylase inhibitors, a purine nucleoside phosphorylase inhibitor, a proteasome inhibitor, and lenalidomide.
American Psychological Association (APA)
Tsukasaki, Kunihiro& Tobinai, Kensei. 2012. Clinical Trials and Treatment of ATL. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-446400
Modern Language Association (MLA)
Tsukasaki, Kunihiro& Tobinai, Kensei. Clinical Trials and Treatment of ATL. Leukemia Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-446400
American Medical Association (AMA)
Tsukasaki, Kunihiro& Tobinai, Kensei. Clinical Trials and Treatment of ATL. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-446400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446400