Activation of PPARγ by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats
Joint Authors
Stewart, Laura Ken
Judd, Robert L.
Coleman, Elaine S.
Akingbemi, Benson
Morrison, Edward
Braden, Tim D.
Plaisance, Eric
Dennis, John
Mansour, Mahmoud M.
Schwartz, Dean D.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor gamma (PPARγ) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats.
This implies modulation of female sex steroid hormones by PPARγ.
It is not clear if PPARγ modulates sex steroid hormones in diabetic males.
Because PPARγ activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long term impact of PPARγ activation on steroid sex hormones in males is critical.
Our objective was to determine the effect of PPARγ activation on serum and intratesticular T, luteinizing hormone (LH), follicle stimulating hormone (FSH) and E2 concentrations in male Zucker diabetic fatty (ZDF) rats treated with the PPARγ agonist rosiglitazone (a thiazolidinedione).
Treatment for eight weeks increased PPARγ mRNA and protein in the testis and elevated serum adiponectin, an adipokine marker for PPARγ activation.
PPARγ activation did not alter serum or intratesticular T concentrations.
In contrast, serum T level but not intratesticular T was reduced by diabetes.
Neither diabetes nor PPARγ activation altered serum E2 or gonadotropins FSH and LH concentrations.
The results suggest that activation of PPARγ by rosiglitazone has no negative impact on sex hormones in male ZDF rats.
American Psychological Association (APA)
Mansour, Mahmoud M.& Coleman, Elaine S.& Dennis, John& Akingbemi, Benson& Schwartz, Dean D.& Braden, Tim D.…[et al.]. 2009. Activation of PPARγ by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats. PPAR Research،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-446412
Modern Language Association (MLA)
Mansour, Mahmoud M.…[et al.]. Activation of PPARγ by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats. PPAR Research No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-446412
American Medical Association (AMA)
Mansour, Mahmoud M.& Coleman, Elaine S.& Dennis, John& Akingbemi, Benson& Schwartz, Dean D.& Braden, Tim D.…[et al.]. Activation of PPARγ by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-446412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446412