Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
Joint Authors
Kanaizumi, Etsuko
Himi, Tetsuo
Shirasaki, Hideaki
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bradykinin (BK) has been tobe thought a potent mediator involved in allergic rhinitis because BK was recovered from the nasal lavage fluid of allergic rhinitis patients after allergen provocation and BK receptor antagonists relief nasal allergic symptoms.
Two mammalian BK receptor subtypes, B1 and B2, have been defined based on their pharmacological properties.
We investigated the localization of these receptors by immunohistochemistry.
Human turbinates were obtained after turbinectomy from 12 patients with nasal obstruction refractory to medical therapy.
The immunohistochemical study revealed that epithelial cells, submucosal glands, fibroblast, vascular smooth muscle, vascular endothelial cells, and macrophages showed immunoreactivity for both B1 and B2 receptors.
The B2 receptor expression was found in peripheral nerve fibers, whereas the B1 expression was not observed in nerves.
The results may have an important clinical implication for understanding the differential roles of BK receptor subtypes on upper airway diseases such as allergic rhinitis and nonallergic rhinitis.
American Psychological Association (APA)
Shirasaki, Hideaki& Kanaizumi, Etsuko& Himi, Tetsuo. 2009. Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-446460
Modern Language Association (MLA)
Shirasaki, Hideaki…[et al.]. Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa. Mediators of Inflammation No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-446460
American Medical Association (AMA)
Shirasaki, Hideaki& Kanaizumi, Etsuko& Himi, Tetsuo. Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-446460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446460