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Resveratrol, MicroRNAs, Inflammation, and Cancer
Joint Authors
Michaille, Jean-Jacques
Tili, Esmerina
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs are short noncoding RNAs that regulate the expression of many target genes posttranscriptionally and are thus implicated in a wide array of cellular and developmental processes.
The expression of miR-155 or miR-21 is upregulated during the course of the inflammatory response, but these microRNAs are also considered oncogenes due to their upregulation of expression in several types of tumors.
Furthermore, it is now well established that inflammation is associated with the induction or the aggravation of nearly 25% of cancers.
Therefore, the above microRNAs are thought to link inflammation and cancer.
Recently, resveratrol (trans-3,4′,5-trihydroxystilbene), a natural polyphenol with antioxidant, anti-inflammatory, and anticancer properties, currently at the stage of preclinical studies for human cancer prevention, has been shown to induce the expression of miR-663, a tumor-suppressor and anti-inflammatory microRNA, while downregulating miR-155 and miR-21.
In this paper we will discuss how the use of resveratrol in therapeutics may benefit from the preanalyses on the status of expression of miR-155 or miR-21 as well as of TGFβ1.
In addition, we will discuss how resveratrol activity might possibly be enhanced by simultaneously manipulating the levels of its key target microRNAs, such as miR-663.
American Psychological Association (APA)
Tili, Esmerina& Michaille, Jean-Jacques. 2011. Resveratrol, MicroRNAs, Inflammation, and Cancer. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-446461
Modern Language Association (MLA)
Tili, Esmerina& Michaille, Jean-Jacques. Resveratrol, MicroRNAs, Inflammation, and Cancer. Journal of Nucleic Acids No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-446461
American Medical Association (AMA)
Tili, Esmerina& Michaille, Jean-Jacques. Resveratrol, MicroRNAs, Inflammation, and Cancer. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-446461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446461