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Renin Angiotensin System in Cognitive Function and Dementia
Joint Authors
Bodiga, Vijaya Lakshmi
Bodiga, Sreedhar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Angiotensin II represents a key molecule in hypertension and cerebrovascular pathology.
By promoting inflammation and oxidative stress, enhanced Ang II levels accelerate the onset and progression of cell senescence.
Sustained activation of RAS promotes end-stage organ injury associated with aging and results in cognitive impairment and dementia.
The discovery of the angiotensin-converting enzyme ACE2-angiotensin (1–7)-Mas receptor axis that exerts vasodilator, antiproliferative, and antifibrotic actions opposed to those of the ACE-Ang II-AT1 receptor axis has led to the hypothesis that a decrease in the expression or activity of angiotensin (1–7) renders the systems more susceptible to the pathological actions of Ang II.
Given the successful demonstration of beneficial effects of increased expression of ACE2/formation of Ang1–7/Mas receptor binding and modulation of Mas expression in animal models in containing cerebrovascular pathology in hypertensive conditions and aging, one could reasonably hope for analogous effects regarding the prevention of cognitive decline by protecting against hypertension and cerebral microvascular damage.
Upregulation of ACE2 and increased balance of Ang 1–7/Ang II, along with positive modulation of Ang II signaling through AT2 receptors and Ang 1–7 signaling through Mas receptors, may be an appropriate strategy for improving cognitive function and treating dementia.
American Psychological Association (APA)
Bodiga, Vijaya Lakshmi& Bodiga, Sreedhar. 2013. Renin Angiotensin System in Cognitive Function and Dementia. Asian Journal of Neuroscience،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-446484
Modern Language Association (MLA)
Bodiga, Vijaya Lakshmi& Bodiga, Sreedhar. Renin Angiotensin System in Cognitive Function and Dementia. Asian Journal of Neuroscience No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-446484
American Medical Association (AMA)
Bodiga, Vijaya Lakshmi& Bodiga, Sreedhar. Renin Angiotensin System in Cognitive Function and Dementia. Asian Journal of Neuroscience. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-446484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446484