Fractalkine and Other Chemokines in Primary Biliary Cirrhosis
Joint Authors
Shimoda, Shinji
Gershwin, M. Eric
Selmi, Carlo
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct.
On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion.
To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine).
We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC.
American Psychological Association (APA)
Shimoda, Shinji& Selmi, Carlo& Gershwin, M. Eric. 2011. Fractalkine and Other Chemokines in Primary Biliary Cirrhosis. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-446514
Modern Language Association (MLA)
Shimoda, Shinji…[et al.]. Fractalkine and Other Chemokines in Primary Biliary Cirrhosis. International Journal of Hepatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-446514
American Medical Association (AMA)
Shimoda, Shinji& Selmi, Carlo& Gershwin, M. Eric. Fractalkine and Other Chemokines in Primary Biliary Cirrhosis. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-446514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446514