Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack)
Joint Authors
Cheng, Yu-Wen
Liao, Jiunn-Wang
Lin, Cheng-Hui
Liao, Po-Lin
Kang, Jaw-Jou
Huang, Wei-Kuang
Li, Ching-Hao
Tse, Ling-Shan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tongkat Ali (Eurycoma longifolia) is an indigenous traditional herb in Southern Asia.
Its powdered root has been processed to produce health supplements, but no detailed toxicology report is available.
In this study, neither mutagenicity nor clastogenicity was noted, and acute oral LD50 was more than 6 g/kg b.w.
After 4-week subacute and 13-week subchronic exposure paradigms (0, 0.6, 1.2, and 2 g/kg b.w./day), adverse effects attributable to test compound were not observed with respect to body weight, hematology, serum biochemistry, urinalysis, macropathology, or histopathology.
However, the treatment significantly reduced prothrombin time, partial thromboplastin time, blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphate kinase, lactate dehydrogenase, and cholesterol levels, especially in males (P<0.05).
These changes were judged as pharmacological effects, and they are beneficial to health.
The calculated acceptable daily intake (ADI) was up to 1.2 g/adult/day.
This information will be useful for product development and safety management.
American Psychological Association (APA)
Li, Ching-Hao& Liao, Jiunn-Wang& Liao, Po-Lin& Huang, Wei-Kuang& Tse, Ling-Shan& Lin, Cheng-Hui…[et al.]. 2013. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-446528
Modern Language Association (MLA)
Li, Ching-Hao…[et al.]. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-446528
American Medical Association (AMA)
Li, Ching-Hao& Liao, Jiunn-Wang& Liao, Po-Lin& Huang, Wei-Kuang& Tse, Ling-Shan& Lin, Cheng-Hui…[et al.]. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-446528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446528