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Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats
Joint Authors
Amin, Zahra A.
Abdulla, Mahmood Ameen
Ismail, Salmah Binti
Alshawsh, Mohammed A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Orthosiphon stamineus as medicinal plant is commonly used in Malaysia for treatment of hepatitis and jaundice; in this study, the ethanol extracts were applied to evaluate the hepatoprotective effects in a thioacetamide-induced hepatotoxic model in Sprague Dawley rats.
Five groups of adult rats were arranged as follows: Group 1 (normal control group), Group 2 Thioacetamide (TAA) as positive control (hepatotoxic group), Group 3 Silymarin as a well-known standard drug (hepatoprotective group), and Groups 4 and 5 as high and low dose (treatment groups).
After 60-day treatment, all rats were sacrificed.
The hepatotoxic group showed a coarse granulation on the liver surface when compared to the smooth aspect observed on the liver surface of the other groups.
Histopathological study confirmed the result; moreover, there was a significant increase in serum liver biochemical parameters (ALT, AST, ALP, and Bilirubin) and the level of liver Malondialdehyde (MDA), accompanied by a significant decrease in the level of total protein and Albumin in the TAA control group when compared with that of the normal group.
The high-dose treatment group (200 mg/kg) significantly restored the elevated liver function enzymes near to normal.
This study revealed that 200 mg/kg extracts of O.
stamineus exerted a hepatoprotective effect.
American Psychological Association (APA)
Alshawsh, Mohammed A.& Abdulla, Mahmood Ameen& Ismail, Salmah Binti& Amin, Zahra A.. 2011. Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-446530
Modern Language Association (MLA)
Alshawsh, Mohammed A.…[et al.]. Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-446530
American Medical Association (AMA)
Alshawsh, Mohammed A.& Abdulla, Mahmood Ameen& Ismail, Salmah Binti& Amin, Zahra A.. Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-446530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446530