The Pathophysiology of HIV-HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders : The Emerging Role of Adipokines
Joint Authors
Palios, John
Lampropoulos, Stylianos
Kadoglou, Nikolaos P. E.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Individuals infected with human immunodeficiency virus (HIV) frequently demonstrate metabolic syndrome (MS) associated with increased incidence of cardiovascular disorders.
Characteristics of HIV infection, such as immunodeficiency, viral load, and duration of the disease, in addition to the highly active antiretroviral therapy (HAART) have been suggested to induce MS in these patients.
It is well documented that MS involves a number of traditional cardiovascular risk factors, like glucose, lipids, and arterial blood pressure abnormalities, leading to extensive atherogenic arterial wall changes.
Nevertheless, the above traditional cardiovascular risk factors merely explain the exacerbated cardiovascular risk in MS.
Nowadays, the adipose-tissue derivatives, known as adipokines, have been suggested to contribute to chronic inflammation and the MS-related cardiovascular disease.
In view of a novel understanding on how adipokines affect the pathogenesis of HIV/HAART-related MS and cardiovascular complications, this paper focuses on the interaction of the metabolic pathways and the potential cardiovascular consequences.
Based on the current literature, we suggest adipokines to have a role in the pathogenesis of the HIV/HAART-related MS.
It is crucial to understand the pathophysiology of the HIV/HAART-related MS and apply therapeutic strategies in order to reduce cardiovascular risk in HIV patients.
American Psychological Association (APA)
Palios, John& Kadoglou, Nikolaos P. E.& Lampropoulos, Stylianos. 2011. The Pathophysiology of HIV-HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders : The Emerging Role of Adipokines. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446535
Modern Language Association (MLA)
Palios, John…[et al.]. The Pathophysiology of HIV-HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders : The Emerging Role of Adipokines. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-446535
American Medical Association (AMA)
Palios, John& Kadoglou, Nikolaos P. E.& Lampropoulos, Stylianos. The Pathophysiology of HIV-HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders : The Emerging Role of Adipokines. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446535