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Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells
Joint Authors
Erenpreisa, Jekaterina
Huna, Anda
Duburs, Gunars
Jascenko, Elina
Salmina, Kristine
Inashkina, Inna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Endopolyploidy and genomic instability are shared features of both stress-induced cellular senescence and malignant growth.
Here, we examined these facets in the widely used normal human fibroblast model of senescence, IMR90.
At the presenescence stage, a small (2–7%) proportion of cells overcome the 4n-G1 checkpoint, simultaneously inducing self-renewal (NANOG-positivity), the DNA damage response (DDR; γ-H2AX-positive foci), and senescence (p16inka4a- and p21CIP1-positivity) signalling, some cells reach octoploid DNA content and divide.
All of these markers initially appear and partially colocalise in the perinucleolar compartment.
Further, with development of senescence and accumulation of p16inka4a and p21CIP1, NANOG is downregulated in most cells.
The cells increasingly arrest in the 4n-G1 fraction, completely halt divisions and ultimately degenerate.
A positive link between DDR, self-renewal, and senescence signalling is initiated in the cells overcoming the tetraploidy barrier, indicating that cellular and molecular context of induced tetraploidy during this period of presenescence is favourable for carcinogenesis.
American Psychological Association (APA)
Huna, Anda& Salmina, Kristine& Jascenko, Elina& Duburs, Gunars& Inashkina, Inna& Erenpreisa, Jekaterina. 2011. Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-446551
Modern Language Association (MLA)
Huna, Anda…[et al.]. Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells. Journal of Aging Research No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-446551
American Medical Association (AMA)
Huna, Anda& Salmina, Kristine& Jascenko, Elina& Duburs, Gunars& Inashkina, Inna& Erenpreisa, Jekaterina. Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-446551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446551