Attenuation Correction for Small Animal PET Images : A Comparison of Two Methods
Joint Authors
Zagni, Federico
D'Ambrosio, Daniela
Spinelli, Antonello E.
Marengo, Mario
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In order to extract quantitative parameters from PET images, several physical effects such as photon attenuation, scatter, and partial volume must be taken into account.
The main objectives of this work were the evaluation of photon attenuation in small animals and the implementation of two attenuation correction methods based on X-rays CT and segmentation of emission images.
The accuracy of the first method with respect to the beam hardening effect was investigated by using Monte Carlo simulations.
Mouse- and rat-sized phantoms were acquired in order to evaluate attenuation correction in terms of counts increment and recovery of uniform activity concentration.
Both methods were applied to mice and rat images acquired with several radiotracers such asF18-FDG, 11C-acetate, 68Ga-chloride, and F18-NaF.
The accuracy of the proposed methods was evaluated in heart and tumour tissues using F18-FDG images and in liver, kidney, and spinal column tissues using C11-acetate, Ga68-chloride, and F18-NaF images, respectively.
In vivo results from animal studies show that, except for bone scans, differences between the proposed methods were about 10% in rats and 3% in mice.
In conclusion, both methods provide equivalent results; however, the segmentation-based approach has several advantages being less time consuming and simple to implement.
American Psychological Association (APA)
D'Ambrosio, Daniela& Zagni, Federico& Spinelli, Antonello E.& Marengo, Mario. 2013. Attenuation Correction for Small Animal PET Images : A Comparison of Two Methods. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-446566
Modern Language Association (MLA)
D'Ambrosio, Daniela…[et al.]. Attenuation Correction for Small Animal PET Images : A Comparison of Two Methods. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-446566
American Medical Association (AMA)
D'Ambrosio, Daniela& Zagni, Federico& Spinelli, Antonello E.& Marengo, Mario. Attenuation Correction for Small Animal PET Images : A Comparison of Two Methods. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-446566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446566