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Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus
Joint Authors
Martin-Eauclaire, Marie-France
Bougis, Pierre E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
K+ channels selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitable and nonexcitable cells.
Their activation allows the cell to repolarize after action potential firing and reduces excitability, whereas channel inhibition increases excitability.
In eukaryotes, the pharmacology and pore topology of several structural classes of K+ channels have been well characterized in the past two decades.
This information has come about through the extensive use of scorpion toxins.
We have participated in the isolation and in the characterization of several structurally distinct families of scorpion toxin peptides exhibiting different K+ channel blocking functions.
In particular, the venom from the Moroccan scorpion Androctonus mauretanicus mauretanicus provided several high-affinity blockers selective for diverse K+ channels (SKCa, Kv4.x, and Kv1.x K+ channel families).
In this paper, we summarize our work on these toxin/channel interactions.
American Psychological Association (APA)
Martin-Eauclaire, Marie-France& Bougis, Pierre E.. 2012. Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-446586
Modern Language Association (MLA)
Martin-Eauclaire, Marie-France& Bougis, Pierre E.. Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus. Journal of Toxicology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-446586
American Medical Association (AMA)
Martin-Eauclaire, Marie-France& Bougis, Pierre E.. Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-446586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446586