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A Randomized Trial Assessing the Effectiveness of Ezetimibe in South Asian Canadians with Coronary Artery Disease or Diabetes : The INFINITY Study
Joint Authors
Khithani, Anil
de Carolis, Emidio
Balleza, Lyn
Vira, Tasnim
Madan, Mina
Rampakakis, Emmanouil
Sampalis, John
Boukas, Stella
Gupta, Anup
Vaillancourt, Julie
Source
Advances in Preventive Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
There is a paucity of data regarding the effectiveness and safety of lipid-lowering treatments among South-Asian patients.
Methods.
Sixty-four South-Asian Canadians with coronary artery disease or diabetes and persistent hypercholesterolemia on statin therapy, were randomized to ezetimibe 10 mg/day co-administered with statin therapy (EZE + Statin) or doubling their current statin dose (STAT2).
Primary outcome was the proportion of patients achieving target LDL-C (<2.0 mmol/L) after 6 weeks.
Secondary outcomes included the change in lipid profile and the incidence of treatment-emergent adverse events through 12 weeks.
Exploratory markers for vascular inflammation were assessed at baseline and 12 weeks.
Results.
At 6 weeks, the primary outcome was significantly higher among the EZE + Statin patients (68% versus 36%; P=0.031) with an OR (95% CI) of 3.97 (1.19, 13.18) upon accounting for baseline LDL-C and adjusting for age.
At 12 weeks, 76% of EZE + Statin patients achieved target LDL-C compared to 48% (P=0.047) of the STAT2 patients (adjusted OR (95% CI) = 3.31 (1.01,10.89)).
No significant between-group differences in exploratory markers were observed with the exception of CRP.
Conclusions.
Patients receiving ezetimibe and statin were more likely to achieve target LDL-C after 6 and 12 weeks compared to patients doubling their statin dose.
Ezetimibe/statin combination therapy was well tolerated among this cohort of South-Asian Canadians, without safety concerns.
American Psychological Association (APA)
Madan, Mina& Vira, Tasnim& Rampakakis, Emmanouil& Gupta, Anup& Khithani, Anil& Balleza, Lyn…[et al.]. 2012. A Randomized Trial Assessing the Effectiveness of Ezetimibe in South Asian Canadians with Coronary Artery Disease or Diabetes : The INFINITY Study. Advances in Preventive Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-446605
Modern Language Association (MLA)
Madan, Mina…[et al.]. A Randomized Trial Assessing the Effectiveness of Ezetimibe in South Asian Canadians with Coronary Artery Disease or Diabetes : The INFINITY Study. Advances in Preventive Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-446605
American Medical Association (AMA)
Madan, Mina& Vira, Tasnim& Rampakakis, Emmanouil& Gupta, Anup& Khithani, Anil& Balleza, Lyn…[et al.]. A Randomized Trial Assessing the Effectiveness of Ezetimibe in South Asian Canadians with Coronary Artery Disease or Diabetes : The INFINITY Study. Advances in Preventive Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-446605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446605