A Novel Rat Model of Type 2 Diabetes : The Zucker Fatty Diabetes Mellitus ZFDM Rat
Joint Authors
Sudo, Katsuko
Yokoi, Norihide
Kawada, Akihiko
Hidaka, Shihomi
Takagi, Sadaaki
Hoshino, Masayuki
Hoshikawa, Ritsuko
Seino, Susumu
Yoshida, Eri
Beppu, Masayuki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Zucker fatty (ZF) rat harboring a missense mutation (fatty, fa) in the leptin receptor gene (Lepr) develops obesity without diabetes; Zucker diabetic fatty (ZDF) rats derived from the ZF strain exhibit obesity with diabetes and are widely used for research on type 2 diabetes (T2D).
Here we establish a novel diabetic strain derived from normoglycemic ZF rats.
In our ZF rat colony, we incidentally found fa/fa homozygous male rats having reproductive ability, which is generally absent in these animals.
During maintenance of this strain by mating fa/fa males and fa/+ heterozygous females, we further identified fa/fa male rats exhibiting diabetes.
We then performed selective breeding using the fa/fa male rats that exhibited relatively high blood glucose levels at 10 weeks of age, resulting in establishment of a diabetic strain that we designated Hos:ZFDM-Leprfa (ZFDM).
These fa/fa male rats developed diabetes as early as 10 weeks of age, reaching 100% incidence by 21 weeks of age, while none of the fa/+ male rats developed diabetes.
The phenotypic characteristics of this diabetic strain are distinct from those of normoglycemic ZF rats.
ZFDM rat strain having high reproductive efficiency should serve as a more useful animal model of T2D.
American Psychological Association (APA)
Yokoi, Norihide& Hoshino, Masayuki& Hidaka, Shihomi& Yoshida, Eri& Beppu, Masayuki& Hoshikawa, Ritsuko…[et al.]. 2013. A Novel Rat Model of Type 2 Diabetes : The Zucker Fatty Diabetes Mellitus ZFDM Rat. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446606
Modern Language Association (MLA)
Yokoi, Norihide…[et al.]. A Novel Rat Model of Type 2 Diabetes : The Zucker Fatty Diabetes Mellitus ZFDM Rat. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-446606
American Medical Association (AMA)
Yokoi, Norihide& Hoshino, Masayuki& Hidaka, Shihomi& Yoshida, Eri& Beppu, Masayuki& Hoshikawa, Ritsuko…[et al.]. A Novel Rat Model of Type 2 Diabetes : The Zucker Fatty Diabetes Mellitus ZFDM Rat. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446606