Characterization of an Effective CTL Response against HIV and SIV Infections
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A vaccine inducing protective immunity in mucosal tissues and secretions may stop or limit HIV infection.
Although cytotoxic T lymphocytes (CTLs) are clearly associated with control of viral replication in HIV and simian immunodeficiency virus (SIV) infections, there are examples of uncontrolled viral replication in the face of strong CD8+ T-cell responses.
The number of functions, breadth, avidity, and magnitude of CTL response are likely to be important factors in the effectiveness of anti-HIV T-cell response, but the location and persistence of effector CD8+ T cells are also critical factors.
Although the only HIV vaccine clinical trial targeting cellular immunity to prevent HIV infection failed, vaccine strategies using persistent agents against pathogenic mucosal challenge in macaque models are showing unique success.
Thus, the key to control the initial focus of viral replication at the portal of entry may rely on the continuous generation of effector CTL responses at mucosal level.
American Psychological Association (APA)
Genescà, Meritxell. 2011. Characterization of an Effective CTL Response against HIV and SIV Infections. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-446632
Modern Language Association (MLA)
Genescà, Meritxell. Characterization of an Effective CTL Response against HIV and SIV Infections. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-446632
American Medical Association (AMA)
Genescà, Meritxell. Characterization of an Effective CTL Response against HIV and SIV Infections. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-446632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446632