Poly(ethylene glycol)-Prodrug Conjugates : Concept, Design, and Applications
Joint Authors
Patil, Rajesh R.
Aher, Naval
Banerjee, Shashwat S.
Khandare, Jayant
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Poly(ethylene glycol) (PEG) is the most widely used polymer in delivering anticancer drugs clinically.
PEGylation (i.e., the covalent attachment of PEG) of peptides proteins, drugs, and bioactives is known to enhance the aqueous solubility of hydrophobic drugs, prolong circulation time, minimize nonspecific uptake, and achieve specific tumor targetability through the enhanced permeability and retention effect.
Numerous PEG-based therapeutics have been developed, and several have received market approval.
A vast amount of clinical experience has been gained which has helped to design PEG prodrug conjugates with improved therapeutic efficacy and reduced systemic toxicity.
However, more efforts in designing PEG-based prodrug conjugates are anticipated.
In light of this, the current paper highlights the synthetic advances in PEG prodrug conjugation methodologies with varied bioactive components of clinical relevance.
In addition, this paper discusses FDA-approved PEGylated delivery systems, their intended clinical applications, and formulations under clinical trials.
American Psychological Association (APA)
Banerjee, Shashwat S.& Aher, Naval& Patil, Rajesh R.& Khandare, Jayant. 2012. Poly(ethylene glycol)-Prodrug Conjugates : Concept, Design, and Applications. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-446638
Modern Language Association (MLA)
Banerjee, Shashwat S.…[et al.]. Poly(ethylene glycol)-Prodrug Conjugates : Concept, Design, and Applications. Journal of Drug Delivery No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-446638
American Medical Association (AMA)
Banerjee, Shashwat S.& Aher, Naval& Patil, Rajesh R.& Khandare, Jayant. Poly(ethylene glycol)-Prodrug Conjugates : Concept, Design, and Applications. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-446638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446638