Quinolinic Acid : An Endogenous Neurotoxin with Multiple Targets
Joint Authors
Lugo-Huitrón, Rafael
Ríos, Camilo
Ugalde Muñiz, Perla
Pineda, Benjamín
Pérez-de la Cruz, Verónica
Pedraza-Chaverri, José
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Quinolinic acid (QUIN), a neuroactive metabolite of the kynurenine pathway, is normally presented in nanomolar concentrations in human brain and cerebrospinal fluid (CSF) and is often implicated in the pathogenesis of a variety of human neurological diseases.
QUIN is an agonist of N-methyl-D-aspartate (NMDA) receptor, and it has a high in vivo potency as an excitotoxin.
In fact, although QUIN has an uptake system, its neuronal degradation enzyme is rapidly saturated, and the rest of extracellular QUIN can continue stimulating the NMDA receptor.
However, its toxicity cannot be fully explained by its activation of NMDA receptors it is likely that additional mechanisms may also be involved.
In this review we describe some of the most relevant targets of QUIN neurotoxicity which involves presynaptic receptors, energetic dysfunction, oxidative stress, transcription factors, cytoskeletal disruption, behavior alterations, and cell death.
American Psychological Association (APA)
Lugo-Huitrón, Rafael& Ugalde Muñiz, Perla& Pineda, Benjamín& Pedraza-Chaverri, José& Ríos, Camilo& Pérez-de la Cruz, Verónica. 2013. Quinolinic Acid : An Endogenous Neurotoxin with Multiple Targets. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-446645
Modern Language Association (MLA)
Lugo-Huitrón, Rafael…[et al.]. Quinolinic Acid : An Endogenous Neurotoxin with Multiple Targets. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-446645
American Medical Association (AMA)
Lugo-Huitrón, Rafael& Ugalde Muñiz, Perla& Pineda, Benjamín& Pedraza-Chaverri, José& Ríos, Camilo& Pérez-de la Cruz, Verónica. Quinolinic Acid : An Endogenous Neurotoxin with Multiple Targets. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-446645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446645