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The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development
Joint Authors
Price, Lawrence H.
Philip, Noah S.
Tyrka, Audrey R.
Carpenter, Linda L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
An important new area of antidepressant drug development involves targeting the nicotinic acetylcholine receptor (nAChR).
This receptor, which is distributed widely in regions of the brain associated with depression, is also implicated in other important processes that are relevant to depression, such as stress and inflammation.
The two classes of drugs that target nAChRs can be broadly divided into mecamylamine- and cytisine-based compounds.
These drugs probably exert their effects via antagonism at α4β2 nAChRs, and strong preclinical data support the antidepressant efficacy of both classes when used in conjunction with other primary antidepressants (e.g., monoamine reuptake inhibitors).
Although clinical data remain limited, preliminary results in this area constitute a compelling argument for further evaluation of the nAChR as a target for future antidepressant drug development.
American Psychological Association (APA)
Philip, Noah S.& Carpenter, Linda L.& Tyrka, Audrey R.& Price, Lawrence H.. 2012. The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446653
Modern Language Association (MLA)
Philip, Noah S.…[et al.]. The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-446653
American Medical Association (AMA)
Philip, Noah S.& Carpenter, Linda L.& Tyrka, Audrey R.& Price, Lawrence H.. The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446653