Numerical Characterization of DNA Sequence Based on Dinucleotides
Joint Authors
Wu, Qin
Fuller, Edgar
Zhang, Cun-Quan
Qi, Xingqin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Sequence comparison is a primary technique for the analysis of DNA sequences.
In order to make quantitative comparisons, one devises mathematical descriptors that capture the essence of the base composition and distribution of the sequence.
Alignment methods and graphical techniques (where each sequence is represented by a curve in high-dimension Euclidean space) have been used popularly for a long time.
In this contribution we will introduce a new nongraphical and nonalignment approach based on the frequencies of the dinucleotide XY in DNA sequences.
The most important feature of this method is that it not only identifies adjacent XY pairs but also nonadjacent XY ones where X and Y are separated by some number of nucleotides.
This methodology preserves information in DNA sequence that is ignored by other methods.
We test our method on the coding regions of exon-1 of β–globin for 11 species, and the utility of this new method is demonstrated.
American Psychological Association (APA)
Qi, Xingqin& Fuller, Edgar& Wu, Qin& Zhang, Cun-Quan. 2012. Numerical Characterization of DNA Sequence Based on Dinucleotides. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-446663
Modern Language Association (MLA)
Qi, Xingqin…[et al.]. Numerical Characterization of DNA Sequence Based on Dinucleotides. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-446663
American Medical Association (AMA)
Qi, Xingqin& Fuller, Edgar& Wu, Qin& Zhang, Cun-Quan. Numerical Characterization of DNA Sequence Based on Dinucleotides. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-446663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446663