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Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Properties of thyme extracts from three different species (Thymus vulgaris, Thymus zygis, and Thymus hyemalis) were examined.
Two oil fractions from each species were obtained by CO2 supercritical fluid extraction.
Main compounds presented in the supercritical extracts of the three thyme varieties were 1,8 cineole, thymol, camphor, borneol, and carvacrol.
As a cellular model of inflammation/atherogenesis, we use human macrophages derived from THP-1 monocytes and activated by oxidized LDLs.
These cells were incubated with the thyme fraction oils, and the productions and gene expressions of the inflammatory mediators TNF-α, IL-1B, IL-6, and IL-10 were determined.
Thyme extracts significantly reduced production and gene expression of the proinflammatory mediators TNF-α, IL-1B, and IL-6 and highly increased these parameters on the anti-inflammatory IL-10 cytokine.
Changes on production and gene expressions were dose dependent and according to the thyme content of each species.
Taken together, these results may suggest that thyme extracts could have anti-inflammatory effects.
American Psychological Association (APA)
Ocaña, A.& Reglero, G.. 2012. Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages. Journal of Obesity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-446707
Modern Language Association (MLA)
Ocaña, A.& Reglero, G.. Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages. Journal of Obesity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-446707
American Medical Association (AMA)
Ocaña, A.& Reglero, G.. Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-446707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446707